Shorter leukocyte telomere length in midlife women with poor sleep quality

Aric A Prather, Eli Puterman, Jue Lin, Aoife O'Donovan, Jeffrey Krauss, A Janet Tomiyama, Elissa S Epel, Elizabeth H Blackburn, Aric A Prather, Eli Puterman, Jue Lin, Aoife O'Donovan, Jeffrey Krauss, A Janet Tomiyama, Elissa S Epel, Elizabeth H Blackburn

Abstract

Background. Accumulating evidence supports leukocyte telomere length (LTL) as a biological marker of cellular aging. Poor sleep is a risk factor for age-related disease; however, the extent to which sleep accounts for variation in LTL is unknown. Methods. The present study examined associations of self-reported sleep duration, onset latency, and subjective quality with LTL in a community-dwelling sample of 245 healthy women in midlife (aged 49-66 years). Results. While sleep duration and onset latency were unrelated to LTL, women reporting poorer sleep quality displayed shorter LTL (r = 0.14, P = 0.03), independent of age, BMI, race, and income (b = 55.48, SE = 27.43, P = 0.04). When analyses were restricted to participants for whom sleep patterns were chronic, poorer sleep quality predicted shorter LTL independent of covariates and perceived psychological stress. Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging.

Figures

Figure 1
Figure 1
Subjective sleep quality is associated with leukocyte telomere length among participants for whom sleep quality rating reflected their “typical” sleep (n = 201), adjusting for age, race, BMI, income, and perceived stress.

References

    1. Vincent GK, Velkoff VA. Current Population Reports: the older population in the United States, 2010 to 2050. 2010. .
    1. Blackburn EH. Structure and function of telomeres. Nature. 1991;350(6319):569–573.
    1. McElhaney JE, Effros RB. Immunosenescence: what does it mean to health outcomes in older adults? Current Opinion in Immunology. 2009;21(4):418–424.
    1. Demissie S, Levy D, Benjamin EJ, et al. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006;5(4):325–330.
    1. Samani NJ, Boultby R, Butler R, Thompson JR, Goodall AH. Telomere shortening in atherosclerosis. The Lancet. 2001;358(9280):472–473.
    1. Sampson MJ, Winterbone MS, Hughes JC, Dozio N, Hughes DA. Monocyte telomere shortening and oxidative DNA damage in type 2 diabetes. Diabetes Care. 2006;29(2):283–289.
    1. Zee RYL, Castonguay AJ, Barton NS, Germer S, Martin M. Mean leukocyte telomere length shortening and type 2 diabetes mellitus: a case-control study. Translational Research. 2010;155(4):166–169.
    1. Cawthon RM, Smith KR, O’Brien E, Sivatchenko A, Kerber RA. Association between telomere length in blood and mortality in people aged 60 years or older. The Lancet. 2003;361(9355):393–395.
    1. Epel ES, Merkin SS, Cawthon R, et al. The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging. 2009;1(1):81–88.
    1. Fitzpatrick AL, Kronmal RA, Kimura M, et al. Leukocyte telomere length and mortality in the cardiovascular health study. The Journals of Gerontology—Series A. 2011;66 A(4):421–429.
    1. Epel ES, Blackburn EH, Lin J, et al. Accelerated telomere shortening in response to life stress. Proceedings of the National Academy of Sciences of the United States of America. 2004;101(49):17312–17315.
    1. O’Donovan A, Lin J, Dhabhar FS, et al. Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain, Behavior, and Immunity. 2009;23(4):446–449.
    1. Nettleton JA, Diez-Roux A, Jenny NS, Fitzpatrick AL, Jacobs DR., Jr. Dietary patterns, food groups, and telomere length in the Multi-Ethnic Study of Atherosclerosis (MESA) The American Journal of Clinical Nutrition. 2008;88(5):1405–1412.
    1. Valdes AM, Andrew T, Gardner JP, et al. Obesity, cigarette smoking, and telomere length in women. The Lancet. 2005;366(9486):662–664.
    1. O'Donnell CJ, Demissie S, Kimura M, et al. Leukocyte telomere length and carotid artery intimal medial thickness: the Framingham Heart Study. Arteriosclerosis, Thrombosis, and Vascular Biology. 2008;28(6):1165–1171.
    1. Cherkas LF, Hunkin JL, Kato BS, et al. The association between physical activity in leisure time and leukocyte telomere length. Archives of Internal Medicine. 2008;168(2):154–158.
    1. LaRocca TJ, Seals DR, Pierce GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mechanisms of Ageing and Development. 2010;131(2):165–167.
    1. Bliwise DL. Normal aging. In: Kryger M, Roth T, Dement WC, editors. Principles and Practice of Sleep Medicine. 5th edition. Philadelphia, Pa, USA: Elsevier Suanders; 2011. pp. 27–41.
    1. Ayas NT, White DP, Manson JE, et al. A prospective study of sleep duration and coronary heart disease in women. Archives of Internal Medicine. 2003;163(2):205–209.
    1. Leineweber C, Kecklund G, Janszky I, Åkerstedt T, Orth-Gomér K. Poor sleep increases the prospective risk for recurrent events in middle-aged women with coronary disease: the Stockholm Female Coronary Risk Study. Journal of Psychosomatic Research. 2003;54(2):121–127.
    1. Mallon L, Broman JE, Hetta J. Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. Journal of Internal Medicine. 2002;251(3):207–216.
    1. Opp MR, Born J, Irwin MR. Sleep and the immune system. In: Ader R, editor. Psychoneuroimmunology. 4th edition. New York, NY, USA: Academic Press; 2007. pp. 570–618.
    1. Buysse DJ, Reynolds CF, III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Research. 1989;28(2):193–213.
    1. Ayas NT, White DP, Al-Delaimy WK, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care. 2003;26(2):380–384.
    1. Cappelleri JC, Bushmakin AG, McDermott AM, Sadosky AB, Petrie CD, Martin S. Psychometric properties of a single-item scale to assess sleep quality among individuals with fibromyalgia. Health and Quality of Life Outcomes. 2009;7, article 54
    1. Caska CM, Hendrickson BE, Wong MH, Ali S, Neylan T, Whooley MA. Anger expression and sleep quality in patients with coronary heart disease: findings from the Heart and Soul Study. Psychosomatic Medicine. 2009;71(3):280–285.
    1. Gangwisch JE, Heymsfield SB, Boden-Albala B, et al. Short sleep duration as a risk factor for hypertension: analyses of the first National Health and Nutrition Examination Survey. Hypertension. 2006;47(5):833–839.
    1. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. Journal of Health and Social Behavior. 1983;24(4):385–396.
    1. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Research. 2002;30(10):p. e47.
    1. Lin J, Epel E, Cheon J, et al. Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. Journal of Immunological Methods. 2010;352(1-2):71–80.
    1. Aviv A, Hunt SC, Lin J, Cao X, Kimura M, Blackburn E. Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR. Nucleic Acids Research. In press.
    1. Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Sleep duration and all-cause mortality: a systematic review and meta-analysis of prospective studies. Sleep. 2010;33(5):585–592.
    1. Lasikiewicz N, Hendrickx H, Talbot D, Dye L. Exploration of basal diurnal salivary cortisol profiles in middle-aged adults: associations with sleep quality and metabolic parameters. Psychoneuroendocrinology. 2008;33(2):143–151.
    1. Zhang J, Ma RC, Kong AP, et al. Relationship of sleep quantity and quality with 24-hour urinary catecholamines and salivary awakening cortisol in healthy middle-aged adults. Sleep. 2011;34(2):225–233.
    1. Prather AA, Marsland AL, Hall M, Neumann SA, Muldoon MF, Manuck SB. Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production. Biological Psychology. 2009;82(1):12–17.
    1. Sahin E, Colla S, Liesa M, et al. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011;470(7334):359–365.
    1. Kiecolt-Glaser JK, Gouin JP, Weng NP, Malarkey WB, Beversdorf DQ, Glaser R. Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation. Psychosomatic Medicine. 2011;73(1):16–22.
    1. O'Donovan A, Epel E, Lin J, et al. Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biological Psychiatry. 2011;70(5):465–471.
    1. Barceló A, Piérola J, López-Escribano H, et al. Telomere shortening in sleep apnea syndrome. Respiratory Medicine. 2010;104(8):1225–1229.
    1. Kim J, Lee S, Bhattacharjee R, Khalyfa A, Kheirandish-Gozal L, Gozal D. Leukocyte telomere length and plasma catestatin and myeloid-related protein 8/14 concentrations in children with obstructive sleep apnea. Chest. 2010;138(1):91–99.

Source: PubMed

Sponzoři a spolupracovníci

Zdravotní podmínky

Drogové intervence

3
Předplatit