Determinants of generic and specific health-related quality of life in patients with Parkinson's disease

Xiao-Jing Tu, Wen-Juh Hwang, Hui-Ing Ma, Ling-Hui Chang, Shih-Pin Hsu, Xiao-Jing Tu, Wen-Juh Hwang, Hui-Ing Ma, Ling-Hui Chang, Shih-Pin Hsu

Abstract

Objectives: Generic and disease-specific health-related quality of life (HRQoL) instruments may reflect different aspects of lives in patients with Parkinson's disease (PD) and thus be associated with different determinants. We used the same cluster of predictors for the generic and disease-specific HRQoL instruments to examine and compare the determinants of HRQoL.

Method: HRQoL was measured in 92 patients with PD by the 36-item Short-Form Health Survey (SF-36) and the 39-item Parkinson's Disease Questionnaire (PDQ-39). The predictors included demographic and disease characteristics, and motor and non-motor symptoms. Multiple regression analyses were used to identify HRQoL determinants.

Results: Depressive symptoms and motor difficulties of daily living were the first two significant determinants for both instruments. The other significant determinant for the SF-36 was fatigue and non-motor difficulties of daily living, and for the PDQ-39 was motor signs of PD.

Conclusions: The results suggest the importance of the evaluation and intervention focused on depressive symptoms and motor difficulties of daily living in patients with PD. In addition, the SF-36 seems more related to non-motor symptoms, while the PDQ-39 appears more associated with motor symptoms. This information is important for understanding results from these two instruments and for choosing which to use.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

    1. Post B, Merkus MP, De Haan RJ, Speelman JD. Prognostic factors for the progression of Parkinson’s disease: A systematic review. Mov Disord. 2007;22(13):1839–51. doi:
    1. Muangpaisan W, Hori H, Brayne C. Systematic Review of the Prevalence and Incidence of Parkinson’s Disease in Asia. J Epidemiol. 2009;19(6):281–93. doi:
    1. Dowding CH, Shenton CL, Salek SS. A review of the health-related quality of life and economic impact of Parkinson’s disease. Drugs Aging. 2006;23(9):693–721.
    1. Reuther M, Spottke EA, Klotsche J, Riedel O, Peter H, Berger K, et al. Assessing health-related quality of life in patients with Parkinson’s disease in a prospective longitudinal study. Parkinsonism Relat Disord. 2007;13(2):108–14. doi:
    1. Soh SE, Morris ME, McGinley JL. Determinants of health-related quality of life in Parkinson’s disease: A systematic review. Parkinsonism Relat Disord. 2011;17(1):1–9. doi:
    1. Martinez-Martin P. An introduction to the concept of "quality of life in Parkinson’s disease". J Neurol. 1998;245:S2–S6.
    1. Martinez-Martin P. The importance of non-motor disturbances to quality of life in Parkinson’s disease. J Neurol Sci. 2011;310(1):12–6.
    1. Patrick DL, Deyo RA. Generic and disease-specific measures in assessing health status and quality of life. Med Care. 1989;27(3):S217–S32.
    1. Guyatt GH, Feeny DH, Patrick DL. Measuring health-related quality of life. Ann Intern Med. 1993;118(8):622–9.
    1. Jenkinson C, Fitzpatrick R, Peto V. Health-related quality-of-life measurement in patients with Parkinson’s disease. Pharmacoeconomics. 1999;15(2):157–65.
    1. Den Oudsten BL, Van Heck GL, De Vries J. The suitability of patient-based measures in the field of Parkinson’s disease: A systematic review. Mov Disord. 2007;22(10):1390–401. doi:
    1. Martinez-Martin P, Jeukens-Visser M, Lyons KE, Rodriguez-Blazquez C, Selai C, Siderowf A, et al. Health-Related Quality-of-Life Scales in Parkinson’s Disease: Critique and Recommendations. Mov Disord. 2011;26(13):2371–80. doi:
    1. Bushnell DM, Martin ML. Quality of life and parkinson’s disease: Translation and validation of the US Parkinson’s Disease Questionnaire (PDQ-39). Qual Life Res. 1999;8(4):345–50.
    1. Ma HI, Hwang WJ, Chen-Sea MJ. Reliability and validity testing of a Chinese-translated version of the 39-item Parkinson’s Disease Questionnaire (PDQ-39). Qual Life Res. 2005;14(2):565–9.
    1. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson’s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatr. 1992;55(3):181–4.
    1. Tariq SH, Tumosa N, Chibnall JT, Perry MH III, Morley JE. Comparison of the Saint Louis University mental status examination and the mini-mental state examination for detecting dementia and mild neurocognitive disorder—a pilot study. Am J Geriatr Psychiatry. 2006;14(11):900–10. doi:
    1. Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez‐Martin P, et al. Movement Disorder Society‐sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS‐UPDRS): Scale presentation and clinimetric testing results. Mov Disord. 2008;23(15):2129–70. doi:
    1. Yu RL, Wu RM, Chan AYY, Mok V, Wu YR, Tilley BC, et al. Cross-Cultural Differences of the Non-Motor Symptoms Studied by the Traditional Chinese Version of the International Parkinson and Movement Disorder Society-Unified Parkinson’s Disease Rating Scale. Mov Disord Clin Prac. 2017;4(1):68–77.
    1. Schrag A, Barone P, Brown RG, Leentjens AFG, McDonald WM, Starkstein S, et al. Depression rating scales in Parkinson’s disease: Critique and recommendations. Mov Disord. 2007;22(8):1077–92. doi:
    1. Friedman JH, Alves G, Hagell P, Marinus J, Marsh L, Martinez‐Martin P, et al. Fatigue rating scales critique and recommendations by the Movement Disorders Society task force on rating scales for Parkinson’s disease. Mov Disord. 2010;25(7):805–22. doi:
    1. Chan ACM. Clinical validation of the Geriatric Depression Scale (GDS)—Chinese version. J Aging Health. 1996;8(2):238–53. doi:
    1. Wang MY, Liu IC, Chiu CH, Tsai PS. Cultural adaptation and validation of the Chinese version of the Fatigue Severity Scale in patients with major depressive disorder and nondepressive people. Qual Life Res. 2016;25(1):89–99. doi:
    1. Hu MH. New choice of a screening tool for cognitive function: The SLUMS test. The Journal of Long-Term Care. 2010;14(3):267–76.
    1. Fuh JL, Wang SJ, Lu SR, Juang KD, Lee SJ. Psychometric evaluation of a Chinese (Taiwanese) version of the SF-36 health survey amongst middle-aged women from a rural community. Qual Life Res. 2000;9(6):675–83.
    1. Den Oudsten BL, Van Heck GL, De Vries J. Quality of life and related concepts in Parkinson’s disease: A systematic review. Mov Disord. 2007;22(11):1528–37. doi:
    1. Schrag A, Jahanshahi M, Quinn N. What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatr. 2000;69(3):308–12. doi:
    1. Caap-Ahlgren M, Dehlin O. Insomnia and depressive symptoms in patients with Parkinson’s disease—Relationship to health-related quality of life. An interview study of patients living at home. Arch Gerontol Geriatr. 2001;32(1):23–33.
    1. Cubo E, Rojo A, Ramos S, Quintana S, Gonzalez M, Kompoliti K, et al. The importance of educational and psychological factors in Parkinson’s disease quality of life. Eur J Neurol. 2002;9(6):589–93.
    1. Grosset KA, Grosset DG. Patient-perceived involvement and satisfaction in Parkinson’s disease: Effect on therapy decisions and quality of life. Mov Disord. 2005;20(5):616–9. doi:
    1. Carod-Artal FJ, Vargas AP, Martinez-Martin P. Determinants of quality of life in Brazilian patients with Parkinson’s disease. Mov Disord. 2007;22(10):1408–15. doi:
    1. Simpson J, Lekwuwa G, Crawford T. Predictors of quality of life in people with Parkinson’s disease: evidence for both domain specific and general relationships. Disabil Rehabil. 2014;36(23):1964–70. doi:
    1. Lawrence BJ, Gasson N, Kane R, Bucks RS, Loftus AM. Activities of Daily Living, Depression, and Quality of Life in Parkinson’s Disease. PLoS ONE. 2014;9(7):e102294 doi:
    1. Rodriguez-Blazquez C, Rojo-Abuin JM, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, Chade A, et al. The MDS-UPDRS Part II (motor experiences of daily living) resulted useful for assessment of disability in Parkinson’s disease. Parkinsonism Relat Disord. 2013;19(10):889–93. doi:
    1. Martinez-Martin P, Rodriguez-Blazquez C, Forjaz MJ, Alvarez-Sanchez M, Arakaki T, Bergareche-Yarza A, et al. Relationship between the MDS-UPDRS domains and the health-related quality of life of Parkinson’s disease patients. Eur J Neurol. 2014;21(3):519–24. doi:
    1. Maetzler W, Liepelt I, Berg D. Progression of Parkinson’s disease in the clinical phase: potential markers. Lancet Neurol. 2009;8(12):1158–71. doi:
    1. Qin Z, Zhang L, Sun F, Liu H, Fang X, Chan P. Depressive symptoms impacting on health-related quality of life in early Parkinson’s disease: Results from Chinese l-dopa exposed cohort. Clin Neurol Neurosurg. 2009;111(9):733–7. doi:
    1. Qin ZH, Zhang LY, Sun F, Fang XH, Meng C, Tanner C, et al. Health related quality of life in early Parkinson’s disease: Impact of motor and non-motor symptoms, results from Chinese levodopa exposed cohort. Parkinsonism Relat Disord. 2009;15(10):767–71. doi:
    1. Müller B, Assmus J, Herlofson K, Larsen JP, Tysnes O-B. Importance of motor vs. non-motor symptoms for health-related quality of life in early Parkinson’s disease. Parkinsonism and Related Disorders. 2013;19(11):1027–32. doi:
    1. Duncan GW, Khoo TK, Yarnall AJ, O'Brien JT, Coleman SY, Brooks DJ, et al. Health‐related quality of life in early Parkinson’s disease: The impact of nonmotor symptoms. Mov Disord. 2014;29(2):195–202. doi:
    1. Skorvanek M, Rosenberger J, Minar M, Grofik M, Han V, Groothoff JW, et al. Relationship between the non-motor items of the MDS–UPDRS and Quality of Life in patients with Parkinson’s disease. J Neurol Sci. 2015;353(1):87–91.
    1. Skorvanek M, Rosenberger J, Gdovinova Z, Nagyova I, Saeedian RG, Groothoff JW, et al. Apathy in Elderly Nondemented Patients With Parkinson’s Disease: Clinical Determinants and Relationship to Quality of Life. J Geriatr Psychiatry Neurol. 2013;26(4):237–43. doi:
    1. Verbaan D, van Rooden SM, Benit CP, van Zwet EW, Marinus J, van Hilten JJ. SPES/SCOPA and MDS-UPDRS: Formulas for converting scores of two motor scales in Parkinson’s disease. Parkinsonism Relat Disord. 2011;17(8):632–4. doi:

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