Early adoption of pharmacogenetic testing for veterans prescribed psychotropic medications
Leland E Hull, Catherine Chanfreau-Coffinier, Sony Tuteja, Dan Berlowitz, Lisa S Lehmann, David W Oslin, Jeffrey M Pyne, Scott L DuVall, Julie A Lynch, Leland E Hull, Catherine Chanfreau-Coffinier, Sony Tuteja, Dan Berlowitz, Lisa S Lehmann, David W Oslin, Jeffrey M Pyne, Scott L DuVall, Julie A Lynch
Abstract
Aim: Describe the characteristics of providers ordering, patients receiving, and clinical impact of a psychotropic pharmacogenetic test on veteran care. Patients & methods: Observational cohort study linking veterans' laboratory results to electronic health record data. Changes in psychotropic medication prescribing were measured as a function of test results. Results: A total of 38 providers tested 181 veterans between 10/6/2014 and 2/1/2018. Prescriptions for medications with severe gene-drug interactions decreased; however, 11 such medications were used after testing. For 43 patients, documentation of the results was missing. Conclusion: Most prescribing decisions were congruent with test results, but in a nontrivial number of cases, prescribers appeared not to act on the results. Poor result documentation impeded the potential of results to inform clinical care.
Trial registration: ClinicalTrials.gov NCT03170362.
Keywords: pharmacogenetic testing; psychotropic medications; veterans.
Source: PubMed