Muscle fibre necrosis induced by intramuscular injection of drugs

D Manor, M Sadeh, D Manor, M Sadeh

Abstract

A number of amphiphilic and lipid-soluble drugs of heterogeneous pharmacological properties, when injected into rat anterior tibial muscles, induced acute muscle fibre necrosis. The myotoxic agents were: penicillin, cloxacillin, phenobarbital, haloperidol, diazepam, hydantoin, metoclopramide, pentazocine and chlorpromazine. The regenerative process, studied using the latter three medications, showed rapid regeneration, complete within 3 weeks. Injection of the water-soluble drugs aminophylline, tranexamic acid and vitamins B6 and B12 produced no tissue damage. The pathogenesis of muscle fibre necrosis is suggested to involve direct damage to cell membranes by lipid soluble drugs.

References

    1. Arch Neurol. 1968 Oct;19(4):384-9
    1. Neurol Clin. 1988 Aug;6(3):593-619
    1. Exp Neurol. 1974 May;43(2):349-58
    1. Exp Neurol. 1974 Dec;45(3):527-40
    1. JAMA. 1975 Nov 10;234(6):621-4
    1. Exp Neurol. 1976 Jul;52(1):40-8
    1. Acta Anat (Basel). 1978;100(3):354-64
    1. Biochem J. 1978 Jan 15;170(1):1-8
    1. Anat Rec. 1978 Jul;191(3):351-69
    1. Toxicol Appl Pharmacol. 1980 Feb;52(2):187-98
    1. Muscle Nerve. 1982 Apr;5(4):281-90
    1. Pediatrics. 1982 Dec;70(6):944-8
    1. J Biochem. 1983 Jul;94(1):1-10
    1. Neurology. 1984 Apr;34(4):524-7
    1. J Neurol Sci. 1985 Feb;67(2):229-38
    1. J Neurol Sci. 1986 Oct;75(3):343-51
    1. Arch Neurol. 1973 Jun;28(6):408-9

Source: PubMed

Sponzoři a spolupracovníci

Zdravotní podmínky

Drogové intervence

3
Předplatit