Changes in Treatment Satisfaction Over 3 Years in Patients With Type 2 Diabetes After Initiating Second-line Treatment

Tomoya Mita, Naoto Katakami, Mitsuyoshi Takahara, Masaru Kawashima, Fumitaka Wada, Hiroki Akiyama, Naru Morita, Yoko Kidani, Toshitaka Yajima, Iichiro Shimomura, Hirotaka Watada, Tomoya Mita, Naoto Katakami, Mitsuyoshi Takahara, Masaru Kawashima, Fumitaka Wada, Hiroki Akiyama, Naru Morita, Yoko Kidani, Toshitaka Yajima, Iichiro Shimomura, Hirotaka Watada

Abstract

Context: J-DISCOVER is a prospective observational cohort study aiming to understand the current management of patients with early-stage type 2 diabetes mellitus (T2DM) in Japan, enrolling patients initiating second-line treatment.

Objective: The current analysis examined the change in treatment satisfaction during the study period and factors affecting this change among patients in J-DISCOVER.

Methods: We used data from the J-DISCOVER study, in which 1798 patients with T2DM aged ≥ 20 years were enrolled from 142 sites across Japan. Treatment satisfaction was assessed using the Diabetes Treatment Satisfaction Questionnaire (DTSQ).

Results: The mean DTSQ treatment satisfaction score increased from 25.9 points at baseline to 27.3 points at 6 months, which was maintained through 36 months. Among the baseline characteristics examined, higher baseline DTSQ treatment satisfaction scores (P < 0.0001), older age (≥ 75 vs < 65 years, P = 0.0096), living alone (P = 0.0356), and type of facility (clinics vs hospitals, P = 0.0044) had a significantly negative impact on the changes in DTSQ treatment satisfaction scores. Improvement in mean glycated hemoglobin (HbA1c) from baseline (7.7%) to 36 months (7.1%) was associated with positive changes in the DTSQ treatment satisfaction score (P = 0.0003).

Conclusion: Changes in DTSQ treatment satisfaction scores were related to HbA1c improvement, suggesting that the management strategy was appropriately planned for each patient. The results also suggest that the availability of social support for patients with T2DM who are elderly or living alone may be an important factor affecting treatment satisfaction, adherence, and clinical outcomes.

Trial registration: ClinicalTrials.gov NCT02322762 NCT02226822.

Keywords: DTSQ; Diabetes Treatment Satisfaction Questionnaire; J-DISCOVER; patient-reported outcome; treatment satisfaction; type 2 diabetes mellitus.

© The Author(s) 2022. Published by Oxford University Press on behalf of the Endocrine Society.

Figures

Figure 1.
Figure 1.
(a), Changes in DTSQ treatment satisfaction scores over time by second-line therapy. Data are shown as mean with SD. (b), Changes in the perceived hyperglycemia frequency scores over time by second-line therapy. Data are shown as mean with SD. (c), Changes in the perceived hypoglycemia frequency scores over time by second-line therapy. Data are shown as mean with SD. Abbreviations: α-GI, α-glucosidase inhibitors; BG, biguanides; DPP-4i, dipeptidyl peptidase-4 inhibitors; DTSQ, Diabetes Treatment Satisfaction Questionnaire; GLP-1RA, glucagon-like peptide-1 receptor agonists; SGLT2i, sodium-glucose cotransporter-2 inhibitors; SU, sulfonylureas; TZD, thiazolidinediones.
Figure 2.
Figure 2.
Changes in the distribution of DTSQ treatment satisfaction score among patients in 6 categorical groups from baseline to 36 months. Patients were categorized into 6 groups based on the DTSQ treatment satisfaction scores at each time point, and the proportions of patients in each category are shown. Abbreviation: DTSQ, Diabetes Treatment Satisfaction Questionnaire.

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Source: PubMed

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