Acute care for patients exposed to a chemical attack: protocol for an international multicentric observational study

Abstract

Introduction: The use of weapons of mass destruction against civilian populations is of serious concern to public health authorities. Chemical weapons are of particular concern. A few studies have investigated medical responses in prehospital settings in the immediate aftermath of a chemical attack, and they were limited by the paucity of clinical data. This study aims to describe the acute management of patients exposed to a chemical attack from the incident site until their transfer to a medical facility.

Methods and analysis: This international multicentric observational study addresses the period from 1970 to 2036. An online electronic case report form was created to collect data; it will be hosted on the Biomedical Telematics Laboratory Platform of the Quebec Respiratory Health Research Network. Participating medical centres and their clinicians are being asked to provide contextual and clinical information, including the use of protective equipment and decontamination capabilities for the medical evacuation of the patient from the incident site of the chemical attack to the moment of admission at the medical facility. In brief, variables are categorised as follows: (1) chemical exposure (threat); (2) prehospital and hospital/medical facility capabilities (staffing, first aid, protection, decontamination, disaster plans and medical guidelines); (3) clinical interventions before hospital admission, including the use of protection and decontamination and (4) outcomes (survivability vs mortality rates). Judgement criteria focus on decontamination drills applied to any of the patient's conditions.

Ethics and dissemination: The Sainte-Justine Research Centre Ethics Committee approved this multicentric study and is acting as the main evaluating centre. Study results will be disseminated through various means, including conferences, indexed publications in medical databases and social media.

Trial registration number: NCT05026645.

Keywords: ACCIDENT & EMERGENCY MEDICINE; EPIDEMIOLOGY; FORENSIC MEDICINE; PUBLIC HEALTH; TOXICOLOGY; TRAUMA MANAGEMENT.

Conflict of interest statement

Competing interests: All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf and declare that no commercial or governmental funding sponsored this project. Jacinthe Leclerc (JC), Philippe Jouvet (PJ), Stephane Bourassa (SB) and Marc Dauphin (MD) have no financial interests that are relevant to the submitted work. Medical Intelligence CBRNE Inc. (also known as MEDINT CBRNE Group) provided a donation for the creation of eCRF. Although SB and MD are MEDINT CBRNE Group founders and shareholders, they have no current financial interests relevant to the submitted work. MEDINT CBRNE Group is a start-up company that was established in 2017 with support from university entrepreneurship services (Laval and Montreal) and the Prince’s Trust Canada (https://www.princesoperationentrepreneur.ca/). The military expertise that has shaped MEDINT CBRNE Group was developed while serving in the Canadian Armed Forces.

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1

Illustration summarising the medical extraction and the zone of interest. This illustration summarises the medical extraction and the study’s zone of interest, which begins at the incident site and ends when the patient is transferred and admitted to the emergency room or its equivalent (eg, a walk-in clinic). Part A. Step 1: patient management begins, step 2: transportation to the medical facility and step 3: patient admission to the emergency room. This is also the point at which continuity of care will normally proceed in a clean zone after patient decontamination. Ideally, the specialised decontamination facility will be located such that the patient will have been decontaminated prior to reaching the hospital. For that reason, it is represented by dashed lines. Emergency services found in cities that have such specialised assets may also have a specialised medical decontamination line that has the highest level of expertise to deal with injured, unconscious and deteriorating patients while they are being processed for a transfer to a clean zone. Part B: illustrates the correspondence between the detection of the patient’s clinical presentation and the medical response during the entire medical extraction. Part C: illustrates the frequency of patient monitoring.