Endovascular Hypothermia in Acute Ischemic Stroke: Pilot Study of Selective Intra-Arterial Cold Saline Infusion
Jian Chen, Liqiang Liu, Hongqi Zhang, Xiaokun Geng, Liqun Jiao, Guilin Li, Jonathan M Coutinho, Yuchuan Ding, David S Liebeskind, Xunming Ji, Jian Chen, Liqiang Liu, Hongqi Zhang, Xiaokun Geng, Liqun Jiao, Guilin Li, Jonathan M Coutinho, Yuchuan Ding, David S Liebeskind, Xunming Ji
Abstract
Background and purpose: We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke.
Methods: Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4°C) in the ischemic territory through the angiographic catheter.
Results: Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2°C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3°C). No obvious complications related to intra-arterial hypothermia were observed.
Conclusions: Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
Keywords: endovascular procedures; hypothermia; intra-arterial infusions; neuroprotection; reperfusion injury.
© 2016 American Heart Association, Inc.
Source: PubMed