Intervention for Varicose Veins of Lower Extremities Lowers the Brain Natriuretic Peptide Values in Varicose Vein Patients
Kiyoshi Tamura, Kiyoshi Tamura
Abstract
Objective: To evaluate the relationship between varicose veins and heart failure, both of which cause edema of lower extremities. Materials and Methods: We enrolled 150 patients who underwent intervention for varicose veins of lower extremities between December 2012 and October 2015, and perioperative data were retrospectively investigated. Results: Of the 150 patients, 104 (69.3%) were females. The mean age was 66.8±10.6 years (27-85 years). Eighty (53.3%) patients had varicose veins in both legs. In all patients, the postoperative (brain natriuretic peptide (BNP) value was significantly lower than the preoperative BNP value (pre : post=39.3 : 30.5 pg/dl, P<0.0001). In patients with higher BNP values (>100 pg/dl), the postoperative BNP values were significantly lower than the preoperative BNP values (pre : post=192.7 : 166.1 pg/dl, P<0.0001). Body weights of the patients decreased differently between pre- and post-operation (pre : post=61.3 : 59.4 kg, P=0.0008). Conclusion: Intervention for varicose veins of lower extremities might be considered clinically useful for the improvement of cardiac function.
Keywords: brain natriuretic peptide; heart failure; varicose vein.
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References
- De Backer G. Epidemiology of chronic venous insufficiency. Angiology 1997; 48: 569-76.
- Carpentier P, Priollet P. Epidemiology of chronic venous insufficiency. Presse Med 1994; 23: 197-201.
- Fowkes FG, Evans CJ, Lee AJ. Prevalence and risk factors of chronic venous insufficiency. Angiology 2001; 52 Suppl. 1: S5-15.
- Cesarone MR, Belcaro G, Nicolaides AN, et al. ‘Real’ epidemiology of varicose veins and chronic venous diseases: the San Valentino Vascular Screening Project. Angiology 2002; 53: 119-30.
- Uema RT, Dezotti NR, Joviliano EE, et al. A prospective study of venous hemodynamics and quality of live at least five years after varicose vein stripping. Acta Cir Bras 2013; 28: 794-9.
- Priollet P. Essential varicose veins and chronic venous insufficiency. Rev Prat 1994; 44: 739-44.
- Tamura K, Nakahara H. MR venography for the assessment of deep vein thrombosis in lower extremities with varicose veins. Ann Vasc Dis 2014; 7: 399-403.
- Nakamura M, Endo H, Nasu M, et al. Value of plasma B type natriuretic peptide measurement for heart disease screening in a Japanese population. Heart 2002; 87: 131-5.
Source: PubMed