T-cell depletion prevents from bronchiolitis obliterans and bronchiolitis obliterans with organizing pneumonia after allogeneic hematopoietic stem cell transplantation with related donors
Markus Ditschkowski, Ahmet H Elmaagacli, Rudolf Trenschel, Rudolf Peceny, Michael Koldehoff, Claudia Schulte, Dietrich W Beelen, Markus Ditschkowski, Ahmet H Elmaagacli, Rudolf Trenschel, Rudolf Peceny, Michael Koldehoff, Claudia Schulte, Dietrich W Beelen
Abstract
Bronchiolitis obliterans (BO) and bronchiolitis obliterans organizing pneumonia (BOOP) are late-onset non-infectious pulmonary complications (LONIPCs) following allogeneic hematopoietic stem cell transplantation (HSCT). In the present study 10 of 197 conventionally prepared stem cell recipients developed BOOP after 365 days and 6 patients developed BO 333 days post-transplant. No BOOP or BO was diagnosed following T-cell depletion (p<0.05). Chronic GVHD was ascertained in all BOOP patients and appeared significantly (p<0,001) more frequent in the conventional transplant group. The data confirm a strong association between T-cell activity, chronic GVHD, BO and BOOP and point out the impact of T lymphocytes in the pathomechanism of BOOP.
Source: PubMed