Preparing for the long-haul: Autonomic complications of COVID-19

Nicholas W Larsen, Lauren E Stiles, Mitchell G Miglis, Nicholas W Larsen, Lauren E Stiles, Mitchell G Miglis

Abstract

As global numbers of COVID-19 grow, chronic neurological symptoms, including those of autonomic dysfunction, are being reported with increasing frequency. Mounting evidence suggests that many patients experience chronic and sometimes debilitating symptoms long after their acute infectious period, leading to the new diagnostic category of post-acute COVID syndrome. Many symptoms of post-acute COVID syndrome appear autonomic in nature, suggesting that autonomic impairment may play a central role in the underlying pathophysiology. In this review, we discuss the autonomic symptoms and manifestations of post-acute COVID syndrome, potential mechanisms involved, and future directions for a better understanding of this novel condition.

Keywords: Autonomic; COVID; Chronic; Dysautonomia; Long-haul COVID; POTS; Post-COVID; Post-acute COVID.

Conflict of interest statement

None.

Copyright © 2021 Elsevier B.V. All rights reserved.

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