High rates of severe disease and death due to SARS-CoV-2 infection in rheumatic disease patients treated with rituximab: a descriptive study

Abstract

The objective of this study is to describe the characteristics and outcomes of rheumatic and musculoskeletal disease (RMD) patients who were treated with rituximab and had suspected or confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In this descriptive study, RMD patients who were treated with rituximab in the last 12 months at the Rheumatology Department of our hospital were screened for SARS-CoV-2 infection via telephone interview and a comprehensive review of clinical health records (01/02/2020-26/05/2020). Those with probable or confirmed SARS-CoV-2 infection were included. In total, 76 patients were screened. Of these, 13 (17.1%) had suspected or confirmed SARS-CoV-2 infection. With regard to these 13 patients, the median age at coronavirus disease (COVID-19) diagnosis was 68 years (range 28-76 years) and 8 (61.5%) were female. Five patients had rheumatoid arthritis, three had systemic vasculitis, two had Sjögren syndrome, and two had systemic lupus erythematosus. Additionally, seven patients (53.8%) had pulmonary involvement secondary to RMD. Eight patients (61.5%) developed severe disease leading to hospitalization, and seven developed bilateral pneumonia and respiratory insufficiency. Of the eight hospitalized patients, five (62.5%) fulfilled the acute respiratory distress syndrome criteria and three developed a critical disease and died. Our cohort had a high rate of severe disease requiring hospitalization (61.5%), with bilateral pneumonia and hyperinflammation leading to a high mortality rate (23.1%). Treatment with rituximab should be considered a possible risk factor for unfavorable outcomes in COVID-19 patients with RMD. However, further study is required to confirm this association.

Keywords: COVID-19; Rheumatic diseases; Rituximab; SARS-CoV-2.

Conflict of interest statement

Dr. Loarce-Martos reports personal fees from Celgene S.L.U., outside the submitted work; Dr. García-Fernández has nothing to disclose; Dr. López-Gutiérrez has nothing to disclose; Dr. García-García has nothing to disclose; Dr. Calvo-Sanz has nothing to disclose; Dr. del Bosque-Granero has nothing to disclose; Dr. Terán-Tinedo has nothing to disclose; Dr. Boteanu has nothing to disclose; Dr. Bachiller-Corral has nothing to disclose; Dr. Vázquez-Díaz reports personal fees and non-financial support from Sandoz, personal fees and non-financial support from Pfizer, personal fees and non-financial support from Merck Sharp and Dohme, outside the submitted work.