High-risk behaviours, and their associations with mental health, adherence to antiretroviral therapy and HIV parameters, in HIV-positive men who have sex with men

Erm Pool, A Winston, E Bagkeris, J H Vera, Pwg Mallon, M Sachikonye, F A Post, A Pozniak, M Boffito, J Anderson, I Williams, M Johnson, L Burgess, C A Sabin, Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study team, Daphne Babalis, Lucy Garvey, Lucy Campbell, Selin Yurdakul, Sara Okumu, Louise Pollard, Beatriz Santana Suárez, Damilola Otiko, Laura Phillips, Rosanna Laverick, Michelle Beynon, Anna-Lena Salz, Abigail Severn, Martin Fisher, Amanda Clarke, Celia Richardson, Sarah Kirk, Rebecca Gleig, Alan Macken, Bijan Ghavani-Kia, Joanne Maher, Maria Byrne, Ailbhe Flaherty, Sumesh Babu, Sifiso Mguni, Rebecca Clark, Rhiannon Nevin-Dolan, Sambasivarao Pelluri, Nnenna Ngwu, Nargis Hemat, Anne Carroll, Sabine Kinloch, Mike Youle, Sara Madge, Andrew Whitehouse, Daphne Babalis, Lucy Garvey, Jonathan Underwood, Lavender Tembo, Matthew Stott, Linda McDonald, Felix Dransfield, Margherita Bracchi, Nicole Pagani, Maddalena Cerrone, Daniel Bradshaw, Francesca Ferretti, Chris Higgs, Elisha Seah, Stephen Fletcher, Michelle Anthonipillai, Ashley Moyes, Katie Deats, Irtiza Syed, Clive Matthews, Peter Fernando, Chido Chiwome, Shane Hardwick, Davide De Francesco, Erm Pool, A Winston, E Bagkeris, J H Vera, Pwg Mallon, M Sachikonye, F A Post, A Pozniak, M Boffito, J Anderson, I Williams, M Johnson, L Burgess, C A Sabin, Pharmacokinetic and Clinical Observations in People over Fifty (POPPY) study team, Daphne Babalis, Lucy Garvey, Lucy Campbell, Selin Yurdakul, Sara Okumu, Louise Pollard, Beatriz Santana Suárez, Damilola Otiko, Laura Phillips, Rosanna Laverick, Michelle Beynon, Anna-Lena Salz, Abigail Severn, Martin Fisher, Amanda Clarke, Celia Richardson, Sarah Kirk, Rebecca Gleig, Alan Macken, Bijan Ghavani-Kia, Joanne Maher, Maria Byrne, Ailbhe Flaherty, Sumesh Babu, Sifiso Mguni, Rebecca Clark, Rhiannon Nevin-Dolan, Sambasivarao Pelluri, Nnenna Ngwu, Nargis Hemat, Anne Carroll, Sabine Kinloch, Mike Youle, Sara Madge, Andrew Whitehouse, Daphne Babalis, Lucy Garvey, Jonathan Underwood, Lavender Tembo, Matthew Stott, Linda McDonald, Felix Dransfield, Margherita Bracchi, Nicole Pagani, Maddalena Cerrone, Daniel Bradshaw, Francesca Ferretti, Chris Higgs, Elisha Seah, Stephen Fletcher, Michelle Anthonipillai, Ashley Moyes, Katie Deats, Irtiza Syed, Clive Matthews, Peter Fernando, Chido Chiwome, Shane Hardwick, Davide De Francesco

Abstract

Objectives: To investigate the patterns and frequency of multiple risk behaviours (alcohol, drugs, smoking, higher risk sexual activity) among men who have sex with men (MSM) living with HIV.

Methods: Cross sectional study.

Results: 147 out of 819 HIV-positive MSM exhibited a high-risk phenotype (defined as >3 of smoking, excess alcohol, sexually transmitted infection and recent recreational drug use). This phenotype was associated with younger age, depressive symptoms and <90% adherence in multivariable logistic regression.

Conclusion: In a cohort of MSM, a small, but significant proportion exhibited multiple concurrent risk behaviours.

Keywords: HIV; adherence; mental health; recreational drugs; risk behaviours.

© 2018 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of British HIV Association.

References

    1. Smith CJ, Ryom L, Weber R et al Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration. Lancet 2014; 384: 241–248.
    1. Parsons JT, Starks TJ, Millar BM, Boonrai K, Marcotte D. Patterns of substance use among HIV‐positive adults over 50: implications for treatment and medication adherence. Drug Alcohol Depend 2014; 139: 33–40.
    1. Singer M. Aids and the health crisis of the U.S. urban poor; the perspective of critical medical anthropology. Soc Sci Med 1994; 39: 931–948.
    1. Khadr SN, Jones KG, Mann S et al Investigating the relationship between substance use and sexual behaviour in young people in Britain: findings from a national probability survey. BMJ Open 2016; 6: e011961.
    1. Elford J, Ibrahim F, Bukutu C, Anderson J. Sexual behaviour of people living with HIV in London: implications for HIV transmission. AIDS 2007; 21 (Suppl 1): S63–S70.
    1. Bourne A, Reid D, Hickson F, Torres‐Rueda S, Weatherburn P. Illicit drug use in sexual settings (‘chemsex’) and HIV/STI transmission risk behaviour among gay men in South London: findings from a qualitative study. Sex Transm Infect 2015; 91: 564–568.
    1. Berg MB, Mimiaga MJ, Safren SA. Mental health concerns of HIV‐infected gay and bisexual men seeking mental health services: an observational study. AIDS Patient Care STDs 2004; 18: 635–643.
    1. Schadé A, van Grootheest G, Smit JH. HIV‐infected mental health patients: characteristics and comparison with HIV‐infected patients from the general population and non‐infected mental health patients. BMC Psychiatry 2013; 13: 35.
    1. Malee K, Mellins CA, Huo Y et al Prevalence, incidence and persistence of psychiatric and substance use disorders among mothers living with HIV. J Acquir Immune Defic Syndr 2014; 65: 526–534.
    1. De Francesco D, Underwood J, Post FA et al Defining cognitive impairment in people‐living‐with‐HIV: the POPPY study. BMC Infect Dis 2016; 16: 617.
    1. Kroenke K, Spitzer RL, Williams JBW. The PHQ‐9: validity of a brief depression severity measure. J Gen Intern Med 2001; 16: 606–613.
    1. Lewinsohn PM, Seeley JR, Roberts RE, Allen NB. Center for Epidemiologic Studies Depression Scale (CES‐D) as a screening instrument for depression among community‐residing older adults. Psychol Aging 1997; 12: 277–287.
    1. Public Health England . HIV: annual data tables (2017). London, UK: 2017.

Source: PubMed

Sponzoři a spolupracovníci

Zdravotní podmínky

Drogové intervence

3
Předplatit