Evaluation of prognostic value of VEGF-C and VEGF-D in breast cancer--10 years follow-up analysis
Iwona Gisterek, Rafał Matkowski, Joanna Koźlak, Danuta Duś, Aleksandra Lacko, Jolanta Szelachowska, Jan Kornafel, Iwona Gisterek, Rafał Matkowski, Joanna Koźlak, Danuta Duś, Aleksandra Lacko, Jolanta Szelachowska, Jan Kornafel
Abstract
The aim of the study was to evaluate the prognostic value of vascular endothelial growth factor C (VEGF-C) and VEGF-D expression in stage II, grade 2 and 3, ductal breast cancer patients.
Patients and methods: The immunohistochemical staining of 98 tumor samples and 5- and 10-year overall (OS) and disease-free survival (DFS) were analyzed.
Results: A significant relationship between VEGF-C and VEGF-D expression (p=0.000002) was noted. No correlations between protein expression and clinical parameters (tumor size, grade, estrogen receptor status, axillaty lymph node metastases and age) or 5- and 10-year DFS or OS were demonstrated. A close to significant correlation (p=0.084) was observed between high expression of VEGF-C and 5-year OS.
Conclusion: Our study did not reveal any prognostic value of VEGF-C or VEGF-D. Therefore they are not useful as markers for patients with poor prognosis. Unlike in other studies, our patient group was homogenous which might have contributed to the results obtained.
Source: PubMed