Effect of sublingual immunotherapy on platelet activity in children with allergic rhinitis

Yanqiu Chen, Lifeng Zhou, Yan Yang, Yanqiu Chen, Lifeng Zhou, Yan Yang

Abstract

Introduction: The role of platelet activation in allergic inflammation is receiving increasing attention. Sublingual immunotherapy for allergic rhinitis can modify the immunological process to an allergen, rather than simply treating symptoms.

Objective: The aim of this study was to explore the role of platelet activation during sublingual immunotherapy in children with allergic rhinitis.

Methods: Forty-two House Dust Mite - sensitized children with allergic rhinitis were enrolled and received House Dust Mite allergen extract for sublingual immunotherapy or placebo. Serum of different time points during treatment was collected and used for detection of Platelet Factor-4 and Beta-Thromboglobulin concentration by Enzyme-Linked Immuno Sorbent Assay.

Results: Our data showed decreased expression of Platelet Factor-4 and Beta-Thromboglobulin protein after one year's sublingual immunotherapy. In addition, the decrease of symptom scores and serum Platelet Factor-4 and Beta-Thromboglobulin protein concentrations was positively related.

Conclusion: During sublingual immunotherapy, platelet activation was inhibited significantly. Our results might indicate that inhibition of platelet activation within the systemic circulation is an important mechanism during sublingual immunotherapy.

Keywords: Allergic rhinitis; Ativação plaquetária; Beta-Thromboglobulin; Beta-tromboglobulina; Fator 4 plaquetário; Imunoterapia sublingual; Platelet Factor-4; Platelet activation; Rinite alérgica; Sublingual immunotherapy.

Copyright © 2016. Published by Elsevier Editora Ltda.

Figures

Figure 1
Figure 1
Serum PF4 and BTG protein expression decreased after 6 months’ SLIT compared with control group and baseline level with significance. The decrease maintained at least one year without rebound (*p < 0.05, comparison between two groups and baseline level; ●, represents for placebo group; ■, represents for SLIT group).
Figure 2
Figure 2
Positive relationship between improvement of symptom scores and decrease of serum PF4 and BTG protein levels of children after one year's SLIT in active treatment group (A and B).

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Source: PubMed

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