Maternal Secretor Status Affects Oral Rotavirus Vaccine Response in Breastfed Infants in Bangladesh

Frank B Williams, Abdul Kader, E Ross Colgate, Dorothy M Dickson, Marya Carmolli, Muhammad Ikhtear Uddin, Salma Sharmin, Shahidul Islam, Taufiqur Rahman Bhuiyan, Masud Alam, Uma Nayak, Josyf C Mychaleckyj, William A Petri, Rashidul Haque, Firdausi Qadri, Beth D Kirkpatrick, Benjamin Lee, Frank B Williams, Abdul Kader, E Ross Colgate, Dorothy M Dickson, Marya Carmolli, Muhammad Ikhtear Uddin, Salma Sharmin, Shahidul Islam, Taufiqur Rahman Bhuiyan, Masud Alam, Uma Nayak, Josyf C Mychaleckyj, William A Petri, Rashidul Haque, Firdausi Qadri, Beth D Kirkpatrick, Benjamin Lee

Abstract

Secretor status controls mucosal histo-blood group antigen expression and is associated with susceptibility to rotavirus (RV) diarrhea, with nonsecretors less susceptible to symptomatic infection. The role of breast milk secretor status on oral live-attenuated RV vaccine response in breastfed infants has not been explored. In a monovalent G1P[8] RV vaccine (Rotarix) trial in Bangladesh, RV-specific plasma immunoglobulin A antibody seroconversion rates were higher among infants of maternal nonsecretors (39%) than infants of maternal secretors (23%; P = .001). Maternal status remained a significant predictor when correcting for infant status (P = .002). Maternal secretor status should be considered when interpreting oral RV vaccine responses in low- and middle-income settings. Clinical Trials Registration. NCT01375647.

Keywords: Breast Milk; Oral vaccine; Rotavirus; Secretor.

© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.

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Source: PubMed

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