Meta-analysis on autologous stem cell transplantation in the treatment of limb ischemic

Abstract

Aim: Meta-analysis on the effectiveness of the autologous stem cell transplantation in curing limb ischemic.

Method: Consulting papers relate to the autologous stem cell transplantation in curing limb ischemic in PubMed, CNKI, Wan-fang Data and VIP. Based on include and exclude standards, we arrange at least 2 evaluators sifting these papers separately, doing Quality evaluation and information extraction and then cross checking. Negotiate through a third party if any disagreement comes out. Review Manager 4.2 is used in Meta-analysis.

Result: Involved 7 papers, all in English version. Patients involved all diagnosed as critical limb ischemia (CLI). Results show that no adverse reaction occurred during this study. Amputation rate in patients with stem cell group treatment is lower than control group (P < 0.05). And no notable difference in improving ABI (P > 0.05).

Conclusions: Applying autologous stem cell transplantation in curing limb ischemic does not have obviously effectiveness in the improvement of ABI of the limb ischemic patients. But it can dramatically reduce the rate of amputation. So autologous stem cell transplantation is a good and safe choice for patients have no choice but amputation.

Keywords: Stem cell; limb ischemic; meta-analysis.

Figures

Figure 1

Put these 7 literatures into funnel plot, and shows that the true value of the included studies is the symmetric distribution center, suggesting that difference is less.

Figure 2

Sensitivity analysis shows the various research studies included did not deviate from the true value was found, the weight is too large or too small.

Figure 3

Various studies by Begg’s test shows Pr > |z| = 0.548 no statistical significance was not found published offset.

Figure 4

The reducing amputation rate compared with the control group shows that autologous stem cell transplantation can significantly reduce the amputation rate among patients with limb ischemia, difference between them has statistically significant.

Figure 5

Prompted in improving ABI, compared with autologous stem cell transplantation shows that the treatment group and the control group had no significant improvement in the treatment, the difference between the two groups has no statistically significance.