Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients

Matteo Winker, Sandra Stössel, Marie Astrid Neu, Nadine Lehmann, Khalifa El Malki, Claudia Paret, Niklas Joisten, Wilhelm Bloch, Philipp Zimmer, Jörg Faber, Matteo Winker, Sandra Stössel, Marie Astrid Neu, Nadine Lehmann, Khalifa El Malki, Claudia Paret, Niklas Joisten, Wilhelm Bloch, Philipp Zimmer, Jörg Faber

Abstract

While exercise and physical activity have been suggested to reduce mortality and symptoms in cancer, knowledge on these associations in patients with childhood cancer (CCPs) is sparse. Anti-inflammatory properties of exercise might mediate these beneficial effects. We investigated the influence of exercise on the inflammation markers neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic-immune-inflammation index (SII) and associations to patient-reported-outcomes in CCPs in a randomized-controlled trial. Results show associations between inflammation markers and patient-reported outcomes. Compared to the control group, SII was significantly reduced following exercise (p=0.036). Anti-inflammatory effects of exercise are also present in CCPs and may underlie exercise-induced benefits on symptoms. Clinical Trial Registration Number: NCT02612025.

Keywords: Cellular inflammation; Endurance training; Pediatric oncology; Resistance training; Tumor entities.

Conflict of interest statement

The authors declare no competing interests.

© 2021. The Author(s).

Figures

Fig. 1
Fig. 1
Correlation analysis (a) of fatigue with Log10-transformed data of (A) NLR, (B) PLR, (C) SII at baseline, as well as QoL with Log10-transformed data of (D) NLR, (E) PLR, and (F) SII at baseline. Log10-transformed data (b) of training effects from pre- (baseline) to post-intervention illustrated as delta values. NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; SII, systemic immune inflammation index; Log10_T0, Log10-transformed data at baseline. Fatigue [total score] evaluated with PedsQL 3.0 questionnaire by parents; QoL [total score] evaluated with KINDL questionnaire by parents. Values are presented as mean ± standard error. *Significant between-group effect

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Source: PubMed

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