Adherence to the Mediterranean diet is associated with lower platelet and leukocyte counts: results from the Moli-sani study
Marialaura Bonaccio, Augusto Di Castelnuovo, Amalia De Curtis, Simona Costanzo, Mariarosaria Persichillo, Maria Benedetta Donati, Chiara Cerletti, Licia Iacoviello, Giovanni de Gaetano, Moli-sani Project Investigators, Licia Iacoviello, Maria Benedetta Donati, Giovanni de Gaetano, Simona Giampaoli, Jos Vermylen, Ignacio De Paula Carrasco, Fabrizio Oleari, Antonio Spagnuolo, Deodato Assanelli, Vincenzo Centritto, Paola Muti, Holger Schünemann, Pasquale Spagnuolo, Dante Staniscia, Francesco Zito, Americo Bonanni, Chiara Cerletti, Amalia De Curtis, Augusto Di Castelnuovo, Licia Iacoviello, Roberto Lorenzet, Antonio Mascioli, Marco Olivieri, Domenico Rotilio, Augusto Di Castelnuovo, Marialaura Bonaccio, Simona Costanzo, Francesco Gianfagna, Marco Olivieri, Maurizio Giacci, Antonella Padulo, Dario Petraroia, Amalia De Curtis, Federico Marracino, Maria Spinelli, Christian Silvestri, Americo Bonanni, Marialaura Bonaccio, Francesca De Lucia, Francesco Gianfagna, Branislav Vohnout, Franco Zito, Mariarosaria Persichillo, Angelita Verna, Maura Di Lillo, Irene Di Stefano, Agostino Pannichella, Antonio Rinaldo Vizzarri, Branislav Vohnout, Agnieszka Pampuch, Antonella Arcari, Daniela Barbato, Francesca Bracone, Simona Costanzo, Carmine Di Giorgio, Sara Magnacca, Simona Panebianco, Antonello Chiovitti, Federico Marracino, Sergio Caccamo, Vanesa Caruso, Livia Rago, Daniela Cugino, Francesco Zito, Francesco Gianfagna, Alessandra Ferri, Concetta Castaldi, Marcella Mignogna, Tomasz Guszcz, Romina di Giuseppe, Paola Barisciano, Lorena Buonaccorsi, Floriana Centritto, Antonella Cutrone, Francesca De Lucia, Francesca Fanelli, Iolanda Santimone, Anna Sciarretta, Maura Di Lillo, Isabella Sorella, Irene Di Stefano, Emanuela Plescia, Alessandra Molinaro, Christiana Cavone, Giovanna Galuppo, Maura Di Lillo, Concetta Castaldi, Dolores D'Angelo, Rosanna Ramacciato, Marialaura Bonaccio, Augusto Di Castelnuovo, Amalia De Curtis, Simona Costanzo, Mariarosaria Persichillo, Maria Benedetta Donati, Chiara Cerletti, Licia Iacoviello, Giovanni de Gaetano, Moli-sani Project Investigators, Licia Iacoviello, Maria Benedetta Donati, Giovanni de Gaetano, Simona Giampaoli, Jos Vermylen, Ignacio De Paula Carrasco, Fabrizio Oleari, Antonio Spagnuolo, Deodato Assanelli, Vincenzo Centritto, Paola Muti, Holger Schünemann, Pasquale Spagnuolo, Dante Staniscia, Francesco Zito, Americo Bonanni, Chiara Cerletti, Amalia De Curtis, Augusto Di Castelnuovo, Licia Iacoviello, Roberto Lorenzet, Antonio Mascioli, Marco Olivieri, Domenico Rotilio, Augusto Di Castelnuovo, Marialaura Bonaccio, Simona Costanzo, Francesco Gianfagna, Marco Olivieri, Maurizio Giacci, Antonella Padulo, Dario Petraroia, Amalia De Curtis, Federico Marracino, Maria Spinelli, Christian Silvestri, Americo Bonanni, Marialaura Bonaccio, Francesca De Lucia, Francesco Gianfagna, Branislav Vohnout, Franco Zito, Mariarosaria Persichillo, Angelita Verna, Maura Di Lillo, Irene Di Stefano, Agostino Pannichella, Antonio Rinaldo Vizzarri, Branislav Vohnout, Agnieszka Pampuch, Antonella Arcari, Daniela Barbato, Francesca Bracone, Simona Costanzo, Carmine Di Giorgio, Sara Magnacca, Simona Panebianco, Antonello Chiovitti, Federico Marracino, Sergio Caccamo, Vanesa Caruso, Livia Rago, Daniela Cugino, Francesco Zito, Francesco Gianfagna, Alessandra Ferri, Concetta Castaldi, Marcella Mignogna, Tomasz Guszcz, Romina di Giuseppe, Paola Barisciano, Lorena Buonaccorsi, Floriana Centritto, Antonella Cutrone, Francesca De Lucia, Francesca Fanelli, Iolanda Santimone, Anna Sciarretta, Maura Di Lillo, Isabella Sorella, Irene Di Stefano, Emanuela Plescia, Alessandra Molinaro, Christiana Cavone, Giovanna Galuppo, Maura Di Lillo, Concetta Castaldi, Dolores D'Angelo, Rosanna Ramacciato
Abstract
Platelet (PLT) and white blood cell (WBC) counts are 2 markers of inflammation and have been linked to the risk for cerebrovascular and coronary heart disease. A Mediterranean diet (MD) has been associated with reduced inflammation and mortality for major chronic diseases. We aimed at evaluating the association between the MD and both PLT and WBC counts. This cross-sectional analysis in a population-based cohort study included 14,586 healthy Italian citizens enrolled within the Moli-sani study. Adherence to MD was appraised by either the MD Score (MDS) or the Italian Mediterranean Index (IMI). PLT and WBC counts were both inversely related to MD adherence (MDS: P < .0001 and P = .008, respectively). As compared with those with poorer MD adherence, subjects with greater adherence had both reduced odds of being in the highest PLT-count group (MDS: odds ratio = 0.50; 95% confidence interval, 0.31-0.80) and increased odds of being in the lowest WBC-count group (IMI: odds ratio = 1.41; 95% confidence interval, 1.07-1.86). The association between WBC count and MDS disappeared when further adjusted for PLT count, whereas the association between PLT count and the MD was not affected by adjustment for WBCs. Food antioxidant and dietary fiber content modified the inverse association between MDS and WBC count and partially accounted for the association with PLTs.
Source: PubMed