Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex

N Gupta, L-C Ang, L Noël de Tilly, L Bidaisee, Y H Yücel, N Gupta, L-C Ang, L Noël de Tilly, L Bidaisee, Y H Yücel

Abstract

The pathology of glaucoma has been extensively studied at the level of the retina and optic nerve head. Here the first clinicopathological case of human glaucoma is reported demonstrating degenerative changes in the brain involving the intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Pathological evidence of neural degeneration in this patient is correlated with clinical, optic nerve head, visual field, and neuroradiology findings. Neuropathology in the glaucoma brain is compared to age matched controls. In the presence of advanced human glaucoma with 50% visual field loss, neural damage is evident in multiple vision stations within the brain.