The role of TNF superfamily members in T-cell function and diseases
Michael Croft, Michael Croft
Abstract
Interactions that occur between several tumour necrosis factor (TNF)-TNF receptors that are expressed by T cells and various other immune and non-immune cell types are central to T-cell function. In this Review, I discuss the biology of four different ligand-receptor interactions - OX40 ligand and OX40, 4-1BB ligand and 4-1BB, CD70 and CD27, and TL1A and death receptor 3 - and their potential to be exploited for therapeutic benefit. Manipulating these interactions can be effective for treating diseases in which T cells have an important role, including inflammatory conditions, autoimmunity and cancer. Here, I explore how blocking or inducing the signalling pathways that are triggered by these different interactions can be an effective way to modulate immune responses.
Figures
![Figure 1. TnF–TnFR family interactions and molecular…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2737409/bin/nihms-123235-f0001.jpg)
![Figure 2. Control of T-cell proliferation by…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2737409/bin/nihms-123235-f0002.jpg)
![Figure 3. TNF–TNFR family interactions regulate many…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2737409/bin/nihms-123235-f0003.jpg)
![Figure 4. modulation of T Reg -cell…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2737409/bin/nihms-123235-f0004.jpg)
Source: PubMed