Effects of Sleep Quality on Melatonin Levels and Inflammatory Response after Major Abdominal Surgery in an Intensive Care Unit

Necdet Fatih Yaşar, Bartu Badak, Ağgül Canik, Sema Şanal Baş, Sema Uslu, Setenay Öner, Ersin Ateş, Necdet Fatih Yaşar, Bartu Badak, Ağgül Canik, Sema Şanal Baş, Sema Uslu, Setenay Öner, Ersin Ateş

Abstract

Disruption of nocturnal sleep in an intensive care unit may remarkably affect production of melatonin, which is also known to have anti-inflammatory properties. In the present study, we aimed to investigate the effect of sleep quality on melatonin levels and inflammation after surgery. Thus, we compared the patients, who were screened in the side-rooms where the lights were dimmed and noise levels were reduced, with the patients who received usual care. Preoperative and postoperative urine 6-sulphatoxymelatonin, serum interleukin-1 (IL-1), interleukin-6 (IL-6), and c-reactive protein (CRP) levels were measured and data on sleep quality was collected using the Richards-Campbell Sleep Questionnaire. Postoperative CRP and IL-6 levels were greater in the control group than in the experimental group, whereas postoperative 24 h melatonin levels were greater than preoperative levels and the difference was steeper in the experimental group in concordance with sleep quality scores. Thus, the regulation of light and noise in ICUs may help the recovery after major surgeries in patients, potentially by increasing melatonin production, which has anti-inflammatory properties.

Keywords: inflammatory response; intensive care unit; melatonin; sleep quality; surgery.

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The effects of controlling noise and light in ICU on plasma CRP levels after major abdominal surgery. * p < 0.001 versus experimental group.
Figure 2
Figure 2
The effects of controlling noise and light in ICU on plasma IL-6 levels after major abdominal surgery. * p = 0.001 versus the experimental group.
Figure 3
Figure 3
The effects of controlling noise and light in ICU on morning aMT6 levels after major abdominal surgery.
Figure 4
Figure 4
The effects of controlling noise and light in ICU on 24-h aMT6 levels after major abdominal surgery. Φp < 0.05 versus preoperative levels in the control group, ‡p < 0.05 versus preoperative levels in the experimental group.

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Source: PubMed

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