Improving outcome for mental disorders by enhancing memory for treatment

Allison G Harvey, Jason Lee, Rita L Smith, Nicole B Gumport, Steven D Hollon, Sophia Rabe-Hesketh, Kerrie Hein, Emily A Dolsen, Kirsten L Haman, Jennifer C Kanady, Monique A Thompson, Deidre Abrons, Allison G Harvey, Jason Lee, Rita L Smith, Nicole B Gumport, Steven D Hollon, Sophia Rabe-Hesketh, Kerrie Hein, Emily A Dolsen, Kirsten L Haman, Jennifer C Kanady, Monique A Thompson, Deidre Abrons

Abstract

Patients exhibit poor memory for treatment. A novel Memory Support Intervention, derived from basic science in cognitive psychology and education, is tested with the goal of improving patient memory for treatment and treatment outcome. Adults with major depressive disorder (MDD) were randomized to 14 sessions of cognitive therapy (CT)+Memory Support (n = 25) or CT-as-usual (n = 23). Outcomes were assessed at baseline, post-treatment and 6 months later. Memory support was greater in CT+Memory Support compared to the CT-as-usual. Compared to CT-as-usual, small to medium effect sizes were observed for recall of treatment points at post-treatment. There was no difference between the treatment arms on depression severity (primary outcome). However, the odds of meeting criteria for 'response' and 'remission' were higher in CT+Memory Support compared with CT-as-usual. CT+Memory Support also showed an advantage on functional impairment. While some decline was observed, the advantage of CT+Memory Support was evident through 6-month follow-up. Patients with less than 16 years of education experience greater benefits from memory support than those with 16 or more years of education. Memory support can be manipulated, may improve patient memory for treatment and may be associated with an improved outcome.

Trial registration: ClinicalTrials.gov NCT01790919.

Keywords: Cognitive therapy; Depression; Memory; Transdiagnostic.

Conflict of interest statement

Declaration of Interests

No authors have a conflict of interest.

Copyright © 2016 Elsevier Ltd. All rights reserved.

Figures

Figure 1
Figure 1
CONSORT Diagram Illustrating the Flow of Participants with Major Depressive Disorder Through the Study
Figure 2
Figure 2
Graph of fitted values derived from three-way interaction (treatment condition x education x time period) HLM. Note. IDS-SR = Inventory of Depressive Symptomatology, Self Report; GAF = Global Assessment of Functioning.
Figure 3
Figure 3
Graph of fitted values derived from three-way interaction (treatment condition x medication x time period) HLM. Note. IDS-SR = Inventory of Depressive Symptomatology, Self Report

Source: PubMed

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