Prognostic value of ejection fraction in patients admitted with acute coronary syndrome: A real world study

Abstract

There are limited data regarding factors affecting outcomes among acute coronary syndrome (ACS) patients presenting with varying degrees of left ventricle (LV) dysfunction. We aimed to identify factors associated with mortality according to LV ejection fraction (LVEF) at 1st admission in ACS patients.A total of 8983 ACS patients prospectively enrolled in the Acute Coronary Syndrome Israeli Survey (2000-2010) were categorized according to their LVEF at admission: severe LV dysfunction (LVEF < 30% [n = 845]), mild-moderate LV dysfunction (LVEF 30%-49% [n = 4470]); preserved LV function (LVEF ≥ 50% [n = 3659]). Multivariable Cox proportional hazards regression modeling was used to assess the risk factors for 1-year mortality according to LVEF on admission.Over the past decade there was a gradual decline in the proportion of patients admitted with low LVEF. Mortality rates were highest among patients with severe LV dysfunction (36%), intermediate among those with mild-moderate LV dysfunction (10%), and lowest among those with preserved LV function (4%, P < 0.001). We recognized different risk factors for mortality according to LVEF at admission. Admission clinical features (syncope, anterior myocardial infarction, and ST elevation myocardial infarction [STEMI]) predicted mortality risk in patients with severe LV dysfunction (all P < 0.05), whereas the presence of comorbidities (hypertension, diabetes mellitus, chronic renal failure, and peripheral arterial disease) predicted mortality risk in patients with more preserved LV function. Age and admission Killip class ≥II were consistent predictors in all LVEF subsets.LVEF at admission is a strong predictor of mortality in ACS, and prognostic factors differ according to LVEF during admission. In patients with severe LV dysfunction signs of clinical instability are related to 1-year mortality; in patients with a more preserved LV function the prognosis is related to the presence of co-morbidities.

Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1

Left ventricle ejection fraction trend over the years of the study in total study population.

Figure 2

Kaplan–Meier survival estimates according to left ventricle ejection fraction groups during 1-year follow-up period.

Figure 3

Kaplan–Meier survival estimates according to admission ST elevation and non-ST elevation during 1-year follow-up period by left ventricle ejection fraction groups. (A) STEMI population. (B) NSTEMI population. NSTEMI = non-ST elevation myocardial infarction, STEMI = ST elevation myocardial infarction.

Figure 4

Kaplan–Meier survival estimates according to diabetes status during 1-year follow-up period by left ventricle ejection fraction groups. (A) Diabetes mellitus population. (B) Nondiabetes mellitus population.