Radiation-induced heart disease: a review of classification, mechanism and prevention

Heru Wang, Jinlong Wei, Qingshuang Zheng, Lingbin Meng, Ying Xin, Xia Yin, Xin Jiang, Heru Wang, Jinlong Wei, Qingshuang Zheng, Lingbin Meng, Ying Xin, Xia Yin, Xin Jiang

Abstract

With the increasing incidence of thoracic tumors, radiation therapy (RT) has become an important component of comprehensive treatment. RT improves survival in many cancers, but it involves some inevitable complications. Radiation-induced heart disease (RIHD) is one of the most serious complications. RIHD comprises a spectrum of heart disease including cardiomyopathy, pericarditis, coronary artery disease, valvular heart disease and conduction system abnormalities. There are numerous clinical manifestations of RIHD, such as chest pain, palpitation, and dyspnea, even without obvious symptoms. Based on previous studies, the pathogenesis of RIHD is related to the production and effects of various cytokines caused by endothelial injury, inflammatory response, and oxidative stress (OS). Therefore, it is of great importance for clinicians to identify the mechanism and propose interventions for the prevention of RIHD.

Keywords: ACE inhibitors.; Radiation-induced heart disease; inflammation; oxidative stress; statins.

Conflict of interest statement

Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

© The author(s).

Figures

Figure 1
Figure 1
The Pathogenesis of RIHD

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