Truncated glucagon-like peptide I, an insulin-releasing hormone from the distal gut
J J Holst, C Orskov, O V Nielsen, T W Schwartz, J J Holst, C Orskov, O V Nielsen, T W Schwartz
Abstract
By hydrophobic gel permeation and high pressure liquid chromatography we isolated from pig intestinal mucosa a peptide which corresponds to proglucagon 78-107 as suggested by chromatography and determination of its N-terminal sequence. Natural and synthetic proglucagon 78-107 dose dependently and potently increased insulin secretion from the isolated perfused pig pancreas. Proglucagon 78-107 also secreted by the small intestine may participate in the hormonal control of insulin secretion.
Source: PubMed