Compliant gluten-free children with celiac disease: an evaluation of psychological distress

Luigi Mazzone, Laura Reale, Massimo Spina, Manuela Guarnera, Elena Lionetti, Serena Martorana, Domenico Mazzone, Luigi Mazzone, Laura Reale, Massimo Spina, Manuela Guarnera, Elena Lionetti, Serena Martorana, Domenico Mazzone

Abstract

Background: Children with chronic illnesses are known to have increased risks for emotional and behavioral problems. In the present study, children and adolescent suffering from celiac disease (CD) were compared with healthy controls to assess differences in the psychological profile.

Methods: A total of 100 well-treated and compliant CD patients (65 females/35 males; age mean ± SD: 10.38 ± 2.71) were compared to 100 normal controls (58 females/42 males; age mean ± SD: 11.47 ± 2.61). Emotional and behavioral problems were assessed by the Child Behavior Checklist (CBCL), the Children's Depression Inventory (CDI) and the Multidimensional Anxiety Scale for Children (MASC).

Results: Subjects with CD self-reported an increased rate of anxiety and depression symptoms and showed higher scores in "harm avoidance" and "somatic complaints", in the CBCL parent-report questionnaire, as compared to healthy control subjects. Furthermore, gender differences could be observed in the group of CD patients, with males displaying significantly higher CBCL externalizing scores, in social, thought and attention problems, as compared to female, who in turns showed more prominent internalizing symptoms such as depression.

Conclusions: The increased rate of emotional and behavioral problems in children and adolescent with CD emphasizes the importance of an early detection of mental health problems in these children.

Figures

Figure 1
Figure 1
MASC profile in celiac (males and females) and normal control subjects. CTRL = normal controls; PS = physical symptoms; HA = harm avoidance; SA = social anxiety; SP = separation anxiety; ADI= Anxiety Disorder Index; TOT = Total
Figure 2
Figure 2
Percent of subjects with MASC scores in the pathological range in control and celiac groups. CTRL = normal controls; T-score > 65 was considered as cut-off for pathological range
Figure 3
Figure 3
CBCL profile in celiac group: gender difference. W = Withdrawn; SC = Somatic Complaint; AD = Anxious/Depressed; SP = Social Problems; TP = Thought Problems; AP = Attention Problems; DB = Delinquent Behavior; AB = Aggressive Behavior

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