Optimizing an mHealth Intervention to Change Food Purchasing Behaviors for Cancer Prevention: Protocol for a Pilot Randomized Controlled Trial

Olivia Z Horgan, Nicole T Crane, Evan M Forman, Brandy-Joe Milliron, Nicole L Simone, Fengqing Zhang, Meghan L Butryn, Olivia Z Horgan, Nicole T Crane, Evan M Forman, Brandy-Joe Milliron, Nicole L Simone, Fengqing Zhang, Meghan L Butryn

Abstract

Background: Dietary intake is a powerful modifiable factor that influences cancer risk; however, most US adults do not adhere to dietary guidelines for cancer prevention. One promising pathway for improving dietary adherence is targeting grocery shopping habits. Interventions might facilitate healthy grocery choices, with a combination of mHealth and traditional methods, by promoting the salience of dietary goals while shopping, enhancing motivation to make dietary changes, and increasing household support for healthy food purchasing.

Objective: This pilot study will assess feasibility and acceptability of intervention components designed to improve adherence to dietary guidelines for cancer prevention (preliminary aim). The primary aim of the study is to quantify the effect of each intervention component, individually and in combination, on dietary intake (primary aim) and grocery store food purchases (exploratory aim). Mediation analyses will be conducted to understand the mechanisms of action (goal salience, motivation, and household support-secondary aims). The overarching goal is to optimize an mHealth intervention to be tested in a future fully powered clinical trial.

Methods: The study enrolled adults (N=62) with low adherence to dietary recommendations for cancer prevention. In a 20-week program, all participants attend a nutrition education workshop and receive weekly educational messages through an app. A factorial design is used to test 4 intervention components: (1) location-triggered messages: educational messages are delivered when arriving at grocery stores; (2) reflections on the benefits of change: content is added to messages to encourage reflection on anticipated benefits of healthy eating, and participants attend an additional workshop session and 3 coach calls on this topic; (3) coach monitoring: food purchases are monitored digitally by a coach who sends personalized weekly app messages and conducts 3 coaching calls that focus on feedback about purchases; and (4) household support: another adult in the household receives messages designed to elicit support for healthy food purchasing, and support is addressed in 3 coach calls and an extra workshop session attended by the index participant and household member. Assessments are completed at weeks 0, 10, and 20 using self-report measures, as well as objective capture of grocery data from the point of purchase using store loyalty accounts.

Results: The National Cancer Institute funded this study (R21CA252933) on July 7, 2020. Participant recruitment began in the spring of 2021 and concluded with the successful enrollment of 62 participants. Data collection is expected to be completed in the summer of 2022, and results are expected to be disseminated in the summer of 2023.

Conclusions: The results of this study will inform the development of scalable interventions to lower cancer risk via changes in dietary intake.

Trial registration: ClinicalTrials.gov NCT04947150; https://ichgcp.net/clinical-trials-registry/NCT04947150.

International registered report identifier (irrid): DERR1-10.2196/39669.

Keywords: cancer prevention; diet; eating; grocery shopping; mHealth; mobile phone.

Conflict of interest statement

Conflicts of Interest: None declared.

©Olivia Z Horgan, Nicole T Crane, Evan M Forman, Brandy-Joe Milliron, Nicole L Simone, Fengqing Zhang, Meghan L Butryn. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 24.06.2022.

Figures

Figure 1
Figure 1
Project EatWell conceptual model.
Figure 2
Figure 2
Project EatWell consort diagram.

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