Acute Perinatal Sentinel Events, Neonatal Brain Injury Pattern, and Outcome of Infants Undergoing a Trial of Hypothermia for Neonatal Hypoxic-Ischemic Encephalopathy
Seetha Shankaran, Abbot R Laptook, Scott A McDonald, Susan R Hintz, Patrick D Barnes, Abhik Das, Rosemary D Higgins, Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, Seetha Shankaran, Abbot R Laptook, Scott A McDonald, Susan R Hintz, Patrick D Barnes, Abhik Das, Rosemary D Higgins, Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network
Abstract
Infants with perinatal sentinel events in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Hypothermia for Encephalopathy Trial had more basal ganglia and thalamus lesions on brain magnetic resonance imaging but similar neurodevelopmental outcomes at 18 months of age than infants without perinatal sentinel events. Outcomes correlated with the neonatal magnetic resonance imaging findings.
Trial registration: ClinicalTrials.gov: NCT00005772.
Keywords: intrapartum event; magnetic resonance imaging; neurodevelopment.
Conflict of interest statement
The authors declare no conflicts of interest.
Copyright © 2016 Elsevier Inc. All rights reserved.
Source: PubMed