EDUC'AVK: reduction of oral anticoagulant-related adverse events after patient education: a prospective multicenter open randomized study
Gilles Pernod, José Labarère, Jacqueline Yver, Bernadette Satger, Benoit Allenet, Touffek Berremili, Michèle Fontaine, Guy Franco, Jean Luc Bosson, Gilles Pernod, José Labarère, Jacqueline Yver, Bernadette Satger, Benoit Allenet, Touffek Berremili, Michèle Fontaine, Guy Franco, Jean Luc Bosson
Abstract
Background: Long-term oral anticoagulation treatment is associated with potential morbidity. Insufficient patient education is linked to poorly controlled anticoagulation. However the impact of a specific educational program on anticoagulation related morbidity remains unknown.
Objective: To evaluate the effect of an oral anticoagulation patient education program in reducing both hemorrhagic and recurrent thrombotic complications.
Design/participants: We conducted a prospective, multicenter open randomized study, comparing an interventional group who received a specific oral anticoagulation treatment educational program with a control group. Eligible patients were older than 18 and diagnosed as having deep vein thrombosis or pulmonary embolism requiring therapy with a vitamin K antagonist for 3 months or more. Our primary outcome was the occurrence of hemorrhagic or thromboembolic events.
Results: During the 3-month follow-up the main outcome criteria were observed 20 times (6.6% of patients), 5 (3.1%) in the experimental and 15 (10.6%) in the control group. Consequently, in multivariate analysis, the cumulative risk reduction in the experimental group was statistically significant (OR 0.25, 95% CI 0.1-0.7, p < 0.01).
Conclusions: Patient education using an educational program reduced VKA-related adverse event rates.
Source: PubMed