Quality of life of colorectal cancer survivors participating in a pilot randomized controlled trial of physical activity trackers and daily text messages

Hilary Chan, Katherine Van Loon, Stacey A Kenfield, June M Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A Meyerhardt, Alan P Venook, Erin L Van Blarigan, Hilary Chan, Katherine Van Loon, Stacey A Kenfield, June M Chan, Emily Mitchell, Li Zhang, Alan Paciorek, Galen Joseph, Angela Laffan, Chloe Atreya, Yoshimi Fukuoka, Christine Miaskowski, Jeffrey A Meyerhardt, Alan P Venook, Erin L Van Blarigan

Abstract

Purpose: There are over 1.3 million colorectal cancer (CRC) survivors in the USA, many of whom report lower health-related quality of life (HRQoL) years after treatment. This study aimed to explore the effect of digital health tools on HRQoL in CRC survivors.

Methods: We conducted a two-arm, randomized controlled trial of 42 subjects who had completed treatment for CRC. Participants in the intervention arm received a Fitbit Flex™ and daily text messages for 12 weeks. HRQoL was assessed as a secondary endpoint in both arms at enrollment and 12 weeks using the Medical Outcomes Study Short Form Survey (SF-36) and the Functional Assessment of Cancer Therapy-Colorectal (FACT-C). Survey score changes from enrollment to 12 weeks were compared between the two arms using independent t tests, and scores at enrollment and 12 weeks were compared using paired t tests.

Results: An increase in the FACT-C functional well-being subscale was observed in individuals in the intervention arm pre- to post-intervention (median difference, 2; interquartile range (IQR), 1, 4; P = .02). Although the between-group comparison was not statistically significant, no change in the functional well-being subscale was observed in the control arm (median difference, 0; IQR, 1, 1; P = .71). No other measures of HRQoL appeared to differ within arm across time points or between arms.

Conclusion: A 12-week digital physical activity intervention may improve functional well-being among CRC survivors. Larger randomized studies are needed to determine if digital health tools improve functional well-being among CRC survivors and if this improvement can be sustained over time.

Trial registration: NCT02966054; registration date, November 17, 2016.

Keywords: Colorectal cancer; Quality of life.

Conflict of interest statement

The authors declare no competing interests.

© 2022. The Author(s).

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