Randomized Control Trial for Reduction of Body Weight, Body Fat Patterning, and Cardiometabolic Risk Factors in Overweight Worksite Employees in Delhi, India

Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra, Usha Shrivastava, Mahrukh Fatma, Smriti Mohan, Padam Singh, Anoop Misra

Abstract

Background: We studied the impact of the multicomponent interventions on body weight and cardiometabolic risk factors in overweight individuals working in corporate worksites.

Methods: Overweight (BMI ≥ 23 kg/m2) subjects were recruited from four randomised worksites [two active intervention (n, recruited, 180, completed 156) and two control (n, recruited 130, completed 111)]. Intensive intervention was given at intervention worksite.

Results: High prevalence (%) of obesity (90.9, 80.2), abdominal obesity (93.5, 84.3), excess skinfold thickness (70.3, 75.9), and low high-density lipoprotein cholesterol (HDL-c) levels (56.8, 63.7) were seen in the intervention and the control group, respectively. At the end of intervention, the following significant changes were observed in the intervention group: decrease in weight, BMI, waist circumference, serum triglycerides, and increase in HDL-c. Weight loss of more than 5% was seen in 12% and 4% individuals in the intervention and control groups, respectively. Most importantly, the sum of all the skinfold measurements (mm) in the intervention group decreased significantly more than the control group (12.51 ± 10.38 versus 3.50 ± 8.18, resp.).

Conclusion: This multicomponent worksite trial showed a reduction in weight, excess subcutaneous fat, and cardiometabolic risk factors after 6 months of active intervention in overweight Asian Indians.

Trial registration: This trial is registered with NCT03249610.

Figures

Figure 1
Figure 1
Screening and recruitment. ∗See text for assessment details. ∗∗See text for methodology of interventions.
Figure 2
Figure 2
Changes in absolute values of skinfold thickness and sum of skinfolds after intervention. All the values are significant ∗Central skinfold is the sum of subscapular and suprailiac skinfolds, peripheral skinfold is the sum of biceps and triceps skinfolds, and the sum of skinfolds is the sum of all the 4 skinfolds (∑4SF, biceps, triceps, subscapular, and suprailiac).
Figure 3
Figure 3
Changes in clustering of risk factors comprising metabolic syndrome before and after intervention. All the values are in the percentage. Please see text for definitions of risk factors.
Figure 4
Figure 4
Change in physical activity profile after intervention. Showing physical activity profile. (a) Preintervention in intervention group (n, 85). (b) Postintervention in the intervention group (n, 80) (c) Preintervention in the control group (n, 85). (d) Postintervention in the control group (n, 80).
Figure 5
Figure 5
Changes in dietary profile after intervention. Showing dietary profile. (a) Preintervention in the intervention group (n, 38). (b) Postintervention in the intervention group (n, 25). (c) Preintervention in the control group (n, 38). (d) Postintervention in the control group (n, 25).

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Source: PubMed

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