Psychological morbidities in adolescent and young adult blood cancer patients during curative-intent therapy and early survivorship
Lori S Muffly, Fay J Hlubocky, Niloufer Khan, Kristen Wroblewski, Katherine Breitenbach, Joseline Gomez, Jennifer L McNeer, Wendy Stock, Christopher K Daugherty, Lori S Muffly, Fay J Hlubocky, Niloufer Khan, Kristen Wroblewski, Katherine Breitenbach, Joseline Gomez, Jennifer L McNeer, Wendy Stock, Christopher K Daugherty
Abstract
Background: Adolescents and young adults (AYAs) with cancer face unique psychosocial challenges. This pilot study was aimed at describing the prevalence of psychological morbidities among AYAs with hematologic malignancies during curative-intent therapy and early survivorship and at examining provider perceptions of psychological morbidities in their AYA patients.
Methods: Patients aged 15 to 39 years with acute leukemia, non-Hodgkin lymphoma, or Hodgkin lymphoma who were undergoing curative-intent therapy (on-treatment group) or were in remission within 2 years of therapy completion (early survivors) underwent a semistructured interview that incorporated measures of anxiety, depression, and posttraumatic stress (PTS). A subset of providers (n = 15) concomitantly completed a survey for each of the first 30 patients enrolled that evaluated their perception of each subject's anxiety, depression, and PTS.
Results: Sixty-one of 77 eligible AYAs participated. The median age at diagnosis was 26 years (range, 15-39 years), 64% were male, and 59% were non-Hispanic white. On-treatment demographics differed significantly from early-survivor demographics only in the median time from diagnosis to interview. Among the 61 evaluable AYAs, 23% met the criteria for anxiety, 28% met the criteria for depression, and 13% met the criteria for PTS; 46% demonstrated PTS symptomatology. Thirty-nine percent were impaired in 1 or more psychological domains. Psychological impairments were as frequent among early survivors as AYAs on treatment. Provider perceptions did not significantly correlate with patient survey results.
Conclusions: AYAs with hematologic malignancies experience substantial psychological morbidities while they are undergoing therapy and during early survivorship, with more than one-third of the patients included in this study meeting the criteria for anxiety, depression, or traumatic stress. This psychological burden may not be accurately identified by their oncology providers.
Keywords: acute leukemia; adolescent and young adult; distress; lymphoma; psycho-oncology; psychosocial oncology; survivorship.
© 2016 American Cancer Society.
Source: PubMed