Assessment of Changes in Concentration of Total Antioxidant Status, Acute-Phase Protein, and Prolactin in Patients with Osteoarthritis Subjected to a Complex Spa Treatment with Radon Water: Preliminary Results

Jadwiga Kuciel-Lewandowska, Michał Kasperczak, Lilla Pawlik-Sobecka, Małgorzata Paprocka-Borowicz, Jan Gnus, Jadwiga Kuciel-Lewandowska, Michał Kasperczak, Lilla Pawlik-Sobecka, Małgorzata Paprocka-Borowicz, Jan Gnus

Abstract

Spa treatment brings many clinical benefits such as improved physical activity, pain relief, and improved quality of life. In the literature, there are only few objective studies evaluating changes in metabolism possibly influencing clinical outcomes. The main purpose of our study was the assessment of the effect of spa treatment on changes in concentration of TAS, CRP, and PRL in patients with osteoarthritis. Patients receiving spa treatment were enrolled. TAS, CRP, and PRL levels were obtained using standard tests before the beginning of treatment as well as on days 5 and 18. The study group consisted of n = 35 patients with peripheral joint and spinal osteoarthritis. The control group consisted of 15 people selected from the resort staff, who also suffered from osteoarthritis and had no contact with radon. An increase in TAS concentration was found in the study group following therapy while the control group was characterized by a significant decrease in TAS. On day 5, an increase in TAS concentration was found in both groups, however, with much worse result in the control group. No changes in CRP concentration were statistically significant. PRL concentration was proven to decrease in a statistically significant way after treatment in the study group. This trial is registered with NCT03274128.

Conflict of interest statement

The authors report no conflicts of interest in this work.

Copyright © 2020 Jadwiga Kuciel-Lewandowska et al.

Figures

Figure 1
Figure 1
TAS—comparison of means in both groups for three tests—Friedman's ANOVA analysis of variance.
Figure 2
Figure 2
Intragroup comparison of CRP results between tests I, II, and III—study group.
Figure 3
Figure 3
Intragroup comparison of CRP results between tests I, II, and III—control group.
Figure 4
Figure 4
Comparison of CRP results between groups—test I.
Figure 5
Figure 5
Comparison of CRP results between groups—test II.
Figure 6
Figure 6
Comparison of CRP results between groups—test III.
Figure 7
Figure 7
Intragroup comparison of prolactin level—study group.
Figure 8
Figure 8
Intragroup comparison of prolactin level—control group.

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