Serial aEEG recordings in a cohort of extremely preterm infants: feasibility and safety

A S Davis, M G Gantz, B Do, S Shankaran, S E G Hamrick, K A Kennedy, J E Tyson, L F Chalak, A R Laptook, R F Goldstein, S R Hintz, A Das, R D Higgins, M B Ball, E C Hale, K P Van Meurs, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Michael S Caplan, Richard A Polin, William Oh, Kristin Basso, Angelita M Hensman, Michael Cotten, Kimberley Fisher, Gloria Siaw, P Brian Smith, James L Wynn, Helmrath Michael, Barbara J Stoll, David P Carlton, Yvonne Loggins, Rosemary D Higgins, Linda L Wright, Stephanie Wilson Archer, Dennis Wallace, Jeanette O'Donnell Auman, James W Pickett 2nd, Kristin M Zaterka-Baxter, David K Stevenson, Melinda S Proud, Pablo J Sanchez, Luc P Brion, Lijun Chen, Nancy A Miller, Diana M Vasil, Katrina Burson, Georgia E McDavid, Patti L Pierce Tate, Peggy Robichaux, Beena G Sood, Rebecca Bara, Mary E Johnson, A S Davis, M G Gantz, B Do, S Shankaran, S E G Hamrick, K A Kennedy, J E Tyson, L F Chalak, A R Laptook, R F Goldstein, S R Hintz, A Das, R D Higgins, M B Ball, E C Hale, K P Van Meurs, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Michael S Caplan, Richard A Polin, William Oh, Kristin Basso, Angelita M Hensman, Michael Cotten, Kimberley Fisher, Gloria Siaw, P Brian Smith, James L Wynn, Helmrath Michael, Barbara J Stoll, David P Carlton, Yvonne Loggins, Rosemary D Higgins, Linda L Wright, Stephanie Wilson Archer, Dennis Wallace, Jeanette O'Donnell Auman, James W Pickett 2nd, Kristin M Zaterka-Baxter, David K Stevenson, Melinda S Proud, Pablo J Sanchez, Luc P Brion, Lijun Chen, Nancy A Miller, Diana M Vasil, Katrina Burson, Georgia E McDavid, Patti L Pierce Tate, Peggy Robichaux, Beena G Sood, Rebecca Bara, Mary E Johnson

Abstract

Objective: Amplitude-integrated electroencephalography (aEEG) monitoring is increasing in the neonatal population, but the safety and feasibility of performing aEEG in extremely preterm infants have not been systematically evaluated.

Study design: Inborn infants 23(0/7) to 28(6/7) weeks gestation or birth weight 401 to 1000 g were eligible. Serial, 6-h aEEG recordings were obtained from first week of life until 36 weeks postmenstrual age. Adverse events were documented, and surveys evaluated the impact of the aEEGs on routine care. Success of performing aEEGs according to protocol and aEEG quality were assessed.

Result: A total of 102 infants were enrolled, with 755 recordings performed. 83% of recordings were performed according to schedule, and 96% were without adverse event. Bedside nurses reported no interference with routine care for 89% of recordings. 92% of recordings had acceptable signal quality.

Conclusion: Serial aEEG monitoring is safe in preterm infants, with few adverse events and general acceptance by nursing staff.

Conflict of interest statement

CONFLICT OF INTEREST

The authors do not declare any conflicts of interest, financial or otherwise.

Figures

Figure 1
Figure 1
Patient flow diagram detailing number of infants screened, eligible, enrolled, and reasons for non-consent.

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Source: PubMed

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