PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE)-a population-based prospective cohort study: rationale, design and baseline participant characteristics

Yuesong Pan, Jing Jing, Xueli Cai, Yilong Wang, Suying Wang, Xia Meng, Chunlai Zeng, Jiong Shi, Jiansong Ji, Jinxi Lin, Lingchun Lyu, Zhe Zhang, Lerong Mei, Shiping Li, Shan Li, Wanlin Zhu, Hao Li, Tiemin Wei, Yongjun Wang, Yuesong Pan, Jing Jing, Xueli Cai, Yilong Wang, Suying Wang, Xia Meng, Chunlai Zeng, Jiong Shi, Jiansong Ji, Jinxi Lin, Lingchun Lyu, Zhe Zhang, Lerong Mei, Shiping Li, Shan Li, Wanlin Zhu, Hao Li, Tiemin Wei, Yongjun Wang

Abstract

Background and purpose: Cardiovascular diseases and dementia are two major diseases in the elderly. Atherosclerosis is associated with future vascular events and cognitive impairment. The PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events (PRECISE) study is a population-based prospective cohort study with comprehensive evaluation of multiterritorial artery stenosis and plaque using advanced vascular imaging techniques and prospective collection of vascular events and cognitive assessments.

Methods: Between May 2017 and September 2019, the PRECISE study enrolled 3067 community-dwelling adults with ages between 50 and 75 years cluster sampled from six villages and four communities of Lishui city in China. Data are collected in face-to-face interviews at baseline, 2-year and 4-year follow-up visits. Brain MRI including high-resolution sequences for intracranial and carotidal arteries and CT angiography for thoracoabdominal arteries were performed at baseline and will be rescanned after 4 years. Cardiovascular/cerebrovascular events and cognitive assessment will be prospectively collected after the enrollment. Blood and urine samples were collected and biomarkers were tested at baseline.

Results: A total of 3067 subjects were enrolled, among which 53.5% were female with an average age of 61.2±6.7 years. Among them, 2.8%, 8.1%, 43.1% and 21.6% had a history of stroke, coronary heart diseases, hypertension and diabetes mellitus, respectively.

Conclusions: The PRECISE study is a population-based prospective cohort study with comprehensive evaluation of atherosclerotic stenosis and plaque using advanced vascular imaging techniques. Data from this cohort provide us an opportunity to precisely evaluate polyvascular atherosclerosis and its association with future vascular events and cognitive impairment.

Trial registration number: ClinicalTrials.gov Registry (NCT03178448).

Keywords: MRI; atherosclerosis; plaque; stroke.

Conflict of interest statement

Competing interests: None declared.

© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1
Figure 1
Flow chart of participant enrollment in the PRECISE study. CTA, CT angiography; PRECISE, PolyvasculaR Evaluation for Cognitive Impairment and vaScular Events.

References

    1. Roth GA, Abate D, Abate KH, et al. . Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the global burden of disease study 2017. The Lancet 2018;392:1736–88. 10.1016/S0140-6736(18)32203-7
    1. GBD 2016 Neurology Collaborators . Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol 2019;18:459–80. 10.1016/S1474-4422(18)30499-X
    1. Roth GA, Johnson C, Abajobir A, et al. . Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol 2017;70:1–25. 10.1016/j.jacc.2017.04.052
    1. GBD 2016 Dementia Collaborators . Global, regional, and national burden of Alzheimer's disease and other dementias, 1990-2016: a systematic analysis for the global burden of disease study 2016. Lancet Neurol 2019;18:88–106. 10.1016/S1474-4422(18)30403-4
    1. Alzheimer's Disease International . World Alzheimer report 2018. The state of the art of dementia research: new frontiers. Available: [Accessed 18 May 2019].
    1. Tosto G, Bird TD, Bennett DA, et al. . The role of cardiovascular risk factors and stroke in familial Alzheimer disease. JAMA Neurol 2016;73:1231–7. 10.1001/jamaneurol.2016.2539
    1. Lourida I, Hannon E, Littlejohns TJ, et al. . Association of lifestyle and genetic risk with incidence of dementia. JAMA 2019;322:430–7. 10.1001/jama.2019.9879
    1. Levine DA, Galecki AT, Langa KM, et al. . Trajectory of cognitive decline after incident stroke. JAMA 2015;314:41–51. 10.1001/jama.2015.6968
    1. Xie W, Zheng F, Yan L, et al. . Cognitive decline before and after incident coronary events. J Am Coll Cardiol 2019;73:3041–50. 10.1016/j.jacc.2019.04.019
    1. Hachinski V, Einhäupl K, Ganten D, et al. . Preventing dementia by preventing stroke: the Berlin manifesto. Alzheimers Dement 2019;15:961–84. 10.1016/j.jalz.2019.06.001
    1. Fernández-Friera L, Peñalvo JL, Fernández-Ortiz A, et al. . Prevalence, vascular distribution, and Multiterritorial extent of subclinical atherosclerosis in a middle-aged cohort: the PESA (progression of early subclinical atherosclerosis) study. Circulation 2015;131:2104–13. 10.1161/CIRCULATIONAHA.114.014310
    1. Steg PG, Bhatt DL, Wilson PWF, et al. . One-Year cardiovascular event rates in outpatients with atherothrombosis. JAMA 2007;297:1197–206. 10.1001/jama.297.11.1197
    1. Bhatt DL, Eagle KA, Ohman EM, et al. . Comparative determinants of 4-year cardiovascular event rates in stable outpatients at risk of or with atherothrombosis. JAMA 2010;304:1350–7. 10.1001/jama.2010.1322
    1. Suri MFK, Qiao Y, Ma X, et al. . Prevalence of intracranial atherosclerotic stenosis using high-resolution magnetic resonance angiography in the general population: the Atherosclerosis risk in Communities study. Stroke 2016;47:1187–93. 10.1161/STROKEAHA.115.011292
    1. Mizukami H, Shimizu T, Maki F, et al. . Progression of intracranial major artery stenosis is associated with baseline carotid and intracranial atherosclerosis. J Atheroscler Thromb 2015;22:183–90. 10.5551/jat.26054
    1. Wang Y, Zhao X, Liu L, et al. . Prevalence and outcomes of symptomatic intracranial large artery stenoses and occlusions in China: the Chinese intracranial atherosclerosis (CICAS) study. Stroke 2014;45:663–9. 10.1161/STROKEAHA.113.003508
    1. Wang Z, Chen Z, Zhang L, et al. . Status of hypertension in China: results from the China hypertension survey, 2012-2015. Circulation 2018;137:2344–56. 10.1161/CIRCULATIONAHA.117.032380
    1. Wang L, Gao P, Zhang M, et al. . Prevalence and ethnic pattern of diabetes and prediabetes in China in 2013. JAMA 2017;317:2515–23. 10.1001/jama.2017.7596
    1. Lu J, Li D, Li F, et al. . Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: a population-based study. J Geriatr Psychiatry Neurol 2011;24:184–90. 10.1177/0891988711422528
    1. Yu J, Li J, Huang X. The Beijing version of the Montreal cognitive assessment as a brief screening tool for mild cognitive impairment: a community-based study. BMC Psychiatry 2012;12:156. 10.1186/1471-244X-12-156
    1. Li H, Jia J, Yang Z. Mini-Mental state examination in elderly Chinese: a population-based normative study. J Alzheimers Dis 2016;53:487–96. 10.3233/JAD-160119
    1. Wang T, Xiao S, Li X, et al. . Reliability and validity of the Chinese version of the neuropsychiatric inventory in mainland China. Int J Geriatr Psychiatry 2012;27:539–44. 10.1002/gps.2757
    1. Chan AC. Clinical validation of the geriatric depression scale (GDS): Chinese version. J Aging Health 1996;8:238–53. 10.1177/089826439600800205
    1. Chen Y, Lv C, Li X, et al. . The positive impacts of early-life education on cognition, leisure activity, and brain structure in healthy aging. Aging 2019;11:4923–42. 10.18632/aging.102088
    1. Song Y, Wu S, Liu X, et al. . Association of systolic blood pressure levels with cardiovascular and cerebrovascular events and all-cause mortality: a result from the Kailuan study. Blood Press Monit 2016;21:149–54. 10.1097/MBP.0000000000000181
    1. National Bureau of Statistics of China . China statistical Yearbook 2018. Beijing: China Statistics Press, 2018.
    1. Wang W, Jiang B, Sun H, et al. . Prevalence, Incidence, and Mortality of Stroke in China: Results from a Nationwide Population-Based Survey of 480 687 Adults. Circulation 2017;135:759–71. 10.1161/CIRCULATIONAHA.116.025250
    1. Qiao Y, Guallar E, Suri FK, et al. . Mr imaging measures of intracranial atherosclerosis in a population-based study. Radiology 2016;280:860–8. 10.1148/radiol.2016151124

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