Impaired autonomic function in adolescents born preterm

Kristin Haraldsdottir, Andrew M Watson, Kara N Goss, Arij G Beshish, David F Pegelow, Mari Palta, Laura H Tetri, Gregory P Barton, Melissa D Brix, Ryan M Centanni, Marlowe W Eldridge, Kristin Haraldsdottir, Andrew M Watson, Kara N Goss, Arij G Beshish, David F Pegelow, Mari Palta, Laura H Tetri, Gregory P Barton, Melissa D Brix, Ryan M Centanni, Marlowe W Eldridge

Abstract

Preterm birth temporarily disrupts autonomic nervous system (ANS) development, and the long-term impacts of disrupted fetal development are unclear in children. Abnormal cardiac ANS function is associated with worse health outcomes, and has been identified as a risk factor for cardiovascular disease. We used heart rate variability (HRV) in the time domain (standard deviation of RR intervals, SDRR; and root means squared of successive differences, RMSSD) and frequency domain (high frequency, HF; and low frequency, LF) at rest, as well as heart rate recovery (HRR) following maximal exercise, to assess autonomic function in adolescent children born preterm. Adolescents born preterm (less than 36 weeks gestation at birth) in 2003 and 2004 and healthy age-matched full-term controls participated. Wilcoxon Rank Sum tests were used to compare variables between control and preterm groups. Twenty-one adolescents born preterm and 20 term-born controls enrolled in the study. Preterm-born subjects had lower time-domain HRV, including SDRR (69.1 ± 33.8 vs. 110.1 ± 33.0 msec, respectively, P = 0.008) and RMSSD (58.8 ± 38.2 vs. 101.5 ± 36.2 msec, respectively, P = 0.012), with higher LF variability in preterm subjects. HRR after maximal exercise was slower in preterm-born subjects at 1 min (30 ± 12 vs. 39 ± 9 bpm, respectively, P = 0.013) and 2 min (52 ± 10 vs. 60 ± 10 bpm, respectively, P = 0.016). This study is the first report of autonomic dysfunction in adolescents born premature. Given prior association of impaired HRV with adult cardiovascular disease, additional investigations into the mechanisms of autonomic dysfunction in this population are warranted.

Keywords: Autonomic function; exercise physiology; heart rate recovery; heart rate variability.

© 2018 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

Figures

Figure 1
Figure 1
Resting heart rate variability. Standard deviation of R‐R intervals, SDRR. B. Root means squared of successive differences, RMSSD. Percentage of differences higher than 50 msec in RR intervals, pRR50. Box and whisker plots describe the mean of the data for each group, with bars showing the max and min values. Data are from 13 control and 12 preterm subjects.
Figure 2
Figure 2
Heart rate recovery following maximal exercise. HRR in control (gray squares) and preterm (open squares) groups. Data are expressed as mean ± SEM. *P < 0.05 adjusted for pairwise comparison between control and preterm groups at each time point.

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