Phenotypic and functional heterogeneity of human memory B cells
Iñaki Sanz, Chungwen Wei, F Eun-Hyung Lee, Jennifer Anolik, Iñaki Sanz, Chungwen Wei, F Eun-Hyung Lee, Jennifer Anolik
Abstract
Memory B cells are more heterogeneous than previously thought. Given that B cells play powerful antibody-independent effector functions, it seems reasonable to assume division of labor between distinct memory B cells subpopulations in both protective and pathogenic immune responses. Here we review the information emerging regarding the heterogeneity of human memory B cells. A better understanding of this topic should greatly improve our ability to target specific B cell subsets either in vaccine responses or in autoimmune diseases and organ rejection among other pathological conditions where B cells play central pathogenic roles.
Figures
![Figure 1. Classification of human B cell…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f1.jpg)
![Figure 2. Multicolor flow cytometry provides a…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f2a.jpg)
![Figure 2. Multicolor flow cytometry provides a…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f2b.jpg)
![Figure 2. Multicolor flow cytometry provides a…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f2c.jpg)
![Figure 3. IgD − CD27 − DN…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f3.jpg)
![Figure 4. IgD + CD27 + unswitched…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f4.jpg)
![Figure 5. The reconstitution profiles of memory…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f5.jpg)
![Figure 6. B cell depletion and TNFα…](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2440717/bin/nihms43448f6.jpg)
Source: PubMed