A randomised comparison of two intranasal dexmedetomidine doses for premedication in children
V M Yuen, T W Hui, M G Irwin, T J Yao, L Chan, G L Wong, M Shahnaz Hasan, I I Shariffuddin, V M Yuen, T W Hui, M G Irwin, T J Yao, L Chan, G L Wong, M Shahnaz Hasan, I I Shariffuddin
Abstract
We compared sedation levels in children following administration of intranasal dexmedetomidine. One hundred and sixteen children aged between 1 and 8 years were enrolled in this prospective, randomised trial. Children were assigned to receive either intranasal dexmedetomidine 1 μg.kg(-1) (Group 1) or 2 μg.kg(-1) (Group 2). Thirty-one (53%) patients from Group 1 and 38 (66%) patients from Group 2 were satisfactorily sedated at the time of anaesthetic induction. Logistic regression showed a significant interaction effect (p=0.049), with the odds ratio between Group 2 over Group 1 estimated as 1.1 (95% CI 0.5-2.7) for the 1-4 year age group, and 10.5 (95% CI 1.4-80.2) for the 5-8 year age group. Both doses produced a similar level of satisfactory sedation in children aged 1-4 years, whereas 2 μg.kg(-1) resulted in a higher proportion of satisfactory sedation in children aged 5-8 years. There were no adverse haemodynamic effects. We conclude that intranasal dexmedetomidine in a premedication dose of 2 μg.kg(-1) resulted in excellent sedation in children.
Anaesthesia © 2012 The Association of Anaesthetists of Great Britain and Ireland.
Source: PubMed