Risk factors for secondary infertility among women in Karachi, Pakistan

Neelofar Sami, Tazeen Saeed Ali, Saba Wasim, Sarah Saleem, Neelofar Sami, Tazeen Saeed Ali, Saba Wasim, Sarah Saleem

Abstract

Background: Secondary infertility in developing countries is mostly attributable to blockage of the fallopian tubes due to adhesions caused by reproductive tract infections. There is a dearth of information on the prevalence and causes of secondary infertility from Pakistan. This paper presents results on factors associated with secondary infertility among married women in Karachi, Pakistan.

Methods: A matched case-control study was conducted. Cases were women aged 15-35 years with history of at least one previous conception and currently seeking treatment for secondary infertility. Controls were women residing in the neighborhood of cases with at least one live birth and not taking treatment for secondary infertility. The age of controls was matched by ±5 years to that of cases. Data was collected from June to August 2003. Conditional logistic regression was used to determine crude and adjusted odds ratios (OR) with corresponding 95% confidence intervals (CI) for factors associated with secondary infertility.

Results: The final multivariate logistic regression model revealed that after adjusting for age, cases were more likely to be the housewives (AOR = 2.6, 95% CI:1.5-4.4), had used inappropriate material to absorb blood during menstruation (AOR = 9.0, 95% CI: 5.0-16.4), and at their last delivery, had a birth attendant who did not wash hands with soap and water (AOR = 3.0, 95% CI: 1.4-5.7). Moreover, women with secondary infertility were more likely to report current or past history of having STI symptoms (AOR = 3.6, 95% CI: 2.4-5.6) and use of intra-vaginal indigenous medicines during their last post-partum period (AOR = 3.1, 95% CI: 1.6-5.7).

Conclusion: We recommend health education and awareness messages for safe practices during menstruation, delivery, and the postpartum period for women in general. Additionally, sanitary napkins should be made available at an affordable cost, and safe delivery kits should contain educational/pictorial brochures for appropriate hand washing skills.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

    1. World Health Organiuzation (WHO) 1994. Challenges in reproductive health research: Biennial Report 1992–1993.
    1. Lunenfeld B, Van Steirteghem A. Infertility in Third Millennium: Implications for the individual, family and society. Condensed meeting Report from the Berterali Foundation's second conference, in Hum Reprod Update. European Society of Human Reproduction and Embryology. 2004:317–326.
    1. WHO. Infertility: a tabulation of available data on prevalence of primary and secondary infertility. 1991. Available: . Accessed 2012 Apr 8.
    1. Boivin J, Bunting L, Collins JA, Nygren KG. International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care. Hum Reprod. 2007;22:1506–1512.
    1. Qureshi MS, Khan T. Infertility in Pakistan; Population Research 1980–1990. 1991. pp. 222–31. National Research Institute of Fertility Control, Karachi.
    1. Spira A. Epidemiology of human reproduction. Hum Reprod. 1986;1:111.
    1. Khatamee MA. Infertility: a preventable epidemic? Int Fertil. 1988;33:246–51.
    1. Farley TMM, Belsey EM. The Prevalence and etiology of Infertility. Proceedings of the African Population Conference, Dakar. 1988.
    1. Cates W, Rolfs RT, Aral SO. Sexually Transmitted Diseases, Pelvic Inflammatory Disease, and Infertility: An Epidemiologic Update. Epidemiologic Review. 1990;12:199–220.
    1. Mayaud P. Infertility in Africa: The Role of Reproductive Tract Infections. In: Boerma T, Mgalla Z, editors. Women and Infertility in Africa: a Multidisciplinary Perspective. Amsterdam: Royal Tropical Institute Press; 2001. pp. 71–107.
    1. Inhorn MC, Buss KA. Infertility, Infection, and Iatrogenesis in Egypt: The Anthropological Epidemiology of Blocked Tubes. In: Inhorn MC, Brown PJ, editors. Anthropology of Infectious Disease: International Health Perspectives. Amsterdam: Gordon and Breach Publishers; 1994. pp. 173–210.
    1. Larsen U. Primary and Secondary Infertility in Tanzania. Journal of Health and Population in Developing Countries. 2003;5:1–15.
    1. Hernadi Z, Smid I, Lampe L. Impact of pregnancy termination and subsequent fertility. Acta Med Hung. 1986;43:155–60.
    1. Anastasia T, Chung-cheng H, Dimitrios T. Induced abortions, miscarriages, and tobacco smoking as risk factors for secondary infertility. Journal of Epidemiology and Community Health. 1993;47:36–39.
    1. Ali T, Sami N, Khawaja A. Are Unhygienic Practices during the Menstrual, Partum and Postpartum Periods Risk Factors for Secondary Infertility? J Health Popul Nutr. 2007;25:189–194.
    1. Kochar M. Etiology of Pelvic Infections Treated by the Gynecologic Service of the Kasturba Hospital, Delhi, India. American Journal of Obstetrics and Gynaecology. 1980;138:872–4.
    1. Goodburn EA, Chowdhury M, Gazi R, Marshall T, Graham W. An investigation into the nature and determinants of maternal morbidity related to delivery and the puerperium in rural Bangladesh. 1994. Maternal and Child Epidemiology Unit, London school of Hygiene and Tropical Medicine, London; Research and Evaluation Division, Dhaka.
    1. Ali T, Fikree F, Rahbar MH, Mahmud S. Frequency and determinants of vaginal infection in postpartum period: a cross-sectional survey from low socioeconomic settlements, Karachi, Pakistan. J Pak Med Assoc. 2006;56:99–103.
    1. Saleem S, Reza T, McClure EM. Chlorhexidine vaginal and neonatal wipes in home births in Pakistan: a randomized controlled trial. Obstet Gynecol. 2007;110:977–85.
    1. WHO factsheet. Proportion of births attended by a skilled health Worker—2008 updates. Geneva: 2008.
    1. Population Council. Reproductive Tract Infection: A set of fact sheets. Bangkok: Population Council; 1999.
    1. Nayab D. Reproductive Tract Infections among Women in Pakistan: An Urban Case Study. The Pakistan Development Review. 2005;44:131–158.
    1. Farr G, Rivera R, Amatya R. Non-physician insertion of IUDs: clinical outcomes among TCu 380A insertions in three developing-country clinics. Adv Cont. 1998;14:45–57.
    1. Bhurt AW, Fikree F. Prevalence and risk factors of symptoms of pelvic inflammatory disease in a rural community of Jamshoro, Sindh, Pakistan. J Pak Med Assoc. 1999;49:188–94.
    1. Hossain MA, Haq MDN, Alam MM. The role of traditional birth attendants in safe delivery practices in rural Bangladesh, Dhaka. NIPORT Dhaka 1989
    1. Alsaawi M, Adamchack DJ. Women's status, fertility and contraceptive use in Khazakstan. GENUS, LVI. 2000;(1–2):99–113.
    1. Sathar Z, Crook N, Callum C, Kazi S. Women's status and fertility change in Pakistan. Population and Development Review. 1988;14:415–432.
    1. United Nations. Women's status and fertility in Pakistan: Recent evidence: Department of Economic and Social Information and Policy Analysis. New York: United Nations; 1993.
    1. WHO. Guidelines for Hand Hygiene in Health Care. Geneva: World Health Organization; 2009.
    1. Larson E. A causal link between hand washing and risk of infection? Examination of the evidence. Infect Control. 1988;9:28–36.
    1. Shahid NS, Greenough WB, Samadi AR, Huq MI. Hand washing with soap reduces diarrhoea and spread of bacterial pathogens in a Bangladesh village. J Diarrhoeal Dis Res. 1996;14:85–89.
    1. Ghani N, Rukanuddin R, Ali T. Prevalence and factors associated with postpartum vaginal infection in the Khyber Agency federally administered tribal areas, Pakistan. J Pak Med Assoc. 2007;57:363–7.
    1. Fikree F, Ali T, Rahbar MH. Traditional Practices, Morbidity and Care Seeking Among 525 Recently Delivered Women in Low Socio-Economic Settlements of Karachi. in Pakistan's Population Stabilization Prospects Conference. Islamabad, Pakistan: Population Council; 2001.
    1. Fikree FF, Ali T, Durocher JM, Rahbar MH. Health service utilization for perceived postpartum morbidity among poor women living in Karachi. Soc Sci Med. 2004;59:681–94.
    1. Abouzahr C, Okonofua F. Infertlity in sub-Saharan Africa. 2003. pp. 128–56. Contemporary Obstetrics and Gynaecology for Developing Countries. Benin City, Nigeria.
    1. Jorn S, Oliver T, Larbi Y, Peter A, Fasching KA, et al. Chlamydia trachomatis Infection as a Risk Factor for Infertility among Women in Ghana, West Africa. Am J Trop Med Hyg. 2008;78:323–327.
    1. Chaturvedi SK, Chandra PS, Issac MK, Sudarshan CY. Somatization misattributed to non-pathological vaginal discharge. J Psychosom Res. 1993;37:575–7.
    1. Mathews A. Menstruation issues in Bangladesh. Footsteps. 1995;24:2–3.
    1. De Silva WI. Puerperal morbidity: A neglected area of maternal health in Sri Lanka. Social Biology. 1998;45:223–45.

Source: PubMed

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