Brain structural covariance networks in obsessive-compulsive disorder: a graph analysis from the ENIGMA Consortium

Je-Yeon Yun, Premika S W Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D Feusner, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A van Wingen, Jian Xu, Xiufeng Xu, Qing Zhao, ENIGMA-OCD working group, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Jun Soo Kwon, Odile A van den Heuvel, Dan J Stein, Premika S W Boedhoe, Paul M Thompson, Neda Jahanshad, Chris Vriend, Yoshinari Abe, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik, K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D Feusner, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erica L Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A van Wingen, Jian Xu, Xiufeng Xu, Je-Yeon Yun, Qing Zhao, Je-Yeon Yun, Premika S W Boedhoe, Chris Vriend, Neda Jahanshad, Yoshinari Abe, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D Feusner, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erika L Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A van Wingen, Jian Xu, Xiufeng Xu, Qing Zhao, ENIGMA-OCD working group, Paul M Thompson, Dan J Stein, Odile A van den Heuvel, Jun Soo Kwon, Odile A van den Heuvel, Dan J Stein, Premika S W Boedhoe, Paul M Thompson, Neda Jahanshad, Chris Vriend, Yoshinari Abe, Stephanie H Ameis, Alan Anticevic, Paul D Arnold, Marcelo C Batistuzzo, Francesco Benedetti, Jan C Beucke, Irene Bollettini, Anushree Bose, Silvia Brem, Anna Calvo, Yuqi Cheng, Kang Ik, K Cho, Valentina Ciullo, Sara Dallaspezia, Damiaan Denys, Jamie D Feusner, Jean-Paul Fouche, Mònica Giménez, Patricia Gruner, Derrek P Hibar, Marcelo Q Hoexter, Hao Hu, Chaim Huyser, Keisuke Ikari, Norbert Kathmann, Christian Kaufmann, Kathrin Koch, Jun Soo Kwon, Luisa Lazaro, Christine Lochner, Paulo Marques, Rachel Marsh, Ignacio Martínez-Zalacaín, David Mataix-Cols, José M Menchón, Luciano Minuzzi, Pedro Morgado, Pedro Moreira, Takashi Nakamae, Tomohiro Nakao, Janardhanan C Narayanaswamy, Erica L Nurmi, Joseph O'Neill, John Piacentini, Fabrizio Piras, Federica Piras, Y C Janardhan Reddy, Joao R Sato, H Blair Simpson, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Michael C Stevens, Philip R Szeszko, David F Tolin, Ganesan Venkatasubramanian, Susanne Walitza, Zhen Wang, Guido A van Wingen, Jian Xu, Xiufeng Xu, Je-Yeon Yun, Qing Zhao

Abstract

Brain structural covariance networks reflect covariation in morphology of different brain areas and are thought to reflect common trajectories in brain development and maturation. Large-scale investigation of structural covariance networks in obsessive-compulsive disorder (OCD) may provide clues to the pathophysiology of this neurodevelopmental disorder. Using T1-weighted MRI scans acquired from 1616 individuals with OCD and 1463 healthy controls across 37 datasets participating in the ENIGMA-OCD Working Group, we calculated intra-individual brain structural covariance networks (using the bilaterally-averaged values of 33 cortical surface areas, 33 cortical thickness values, and six subcortical volumes), in which edge weights were proportional to the similarity between two brain morphological features in terms of deviation from healthy controls (i.e. z-score transformed). Global networks were characterized using measures of network segregation (clustering and modularity), network integration (global efficiency), and their balance (small-worldness), and their community membership was assessed. Hub profiling of regional networks was undertaken using measures of betweenness, closeness, and eigenvector centrality. Individually calculated network measures were integrated across the 37 datasets using a meta-analytical approach. These network measures were summated across the network density range of K = 0.10-0.25 per participant, and were integrated across the 37 datasets using a meta-analytical approach. Compared with healthy controls, at a global level, the structural covariance networks of OCD showed lower clustering (P < 0.0001), lower modularity (P < 0.0001), and lower small-worldness (P = 0.017). Detection of community membership emphasized lower network segregation in OCD compared to healthy controls. At the regional level, there were lower (rank-transformed) centrality values in OCD for volume of caudate nucleus and thalamus, and surface area of paracentral cortex, indicative of altered distribution of brain hubs. Centrality of cingulate and orbito-frontal as well as other brain areas was associated with OCD illness duration, suggesting greater involvement of these brain areas with illness chronicity. In summary, the findings of this study, the largest brain structural covariance study of OCD to date, point to a less segregated organization of structural covariance networks in OCD, and reorganization of brain hubs. The segregation findings suggest a possible signature of altered brain morphometry in OCD, while the hub findings point to OCD-related alterations in trajectories of brain development and maturation, particularly in cingulate and orbitofrontal regions.

Keywords: brain structural covariance network; graph theory; illness duration; obsessive-compulsive disorder; pharmacotherapy.

© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.

Figures

Figure 1
Figure 1
Schematic description of the study procedures: construction of intra-individual brain structural covariance networks. HC = healthy controls; L = left; M = mean; R = right; ROI = region of interest; SD = standard deviation.
Figure 2
Figure 2
Schematic description of the study procedures. (A) Calculation of graph theory metrics from the intra-individual brain structural covariance networks at single-subject level and (B) meta-analytic integration of graph theory metrics for 37 datasets. HC = healthy controls; ROI = region of interest.
Figure 3
Figure 3
Forest plots of the meta-analysis of global graph metrics comparying the OCD and healthy control groups. (A) Global clustering, (B) small-worldness, (C) modularity, (D) global efficiency, and (E) dice similarity coefficient. HC = healthy controls; ROI = region of interest.
Figure 4
Figure 4
Meta-analysis of community membership and hubs. (A) Healthy bontrols (HC); and (B) OCD. Spheres represent nodes [= bilaterally-averaged values of 33 cortical surface areas (CSAs), 33 cortical thickness (CT), and six subcortical volumes (vol)] comprising the intra-individual structural covariance network. Larger spheres represent hubs, and differential colours were used to denote the spheres (or network nodes) segregated as different modules.
Figure 5
Figure 5
Meta-analysis of regional network characteristics (= rank-transformed betweenness, closeness, and eigenvector centralities). (A) Comparing OCD and healthy controls (HC); (B) comparing medicated OCD with unmedicated OCD; and (C) estimating the degrees of relationship with illness duration for OCD. CSA = cortical surface areas; CT = cortical thickness.

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Source: PubMed

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