Sarcopenia for predicting falls and hospitalization in community-dwelling older adults: EWGSOP versus EWGSOP2

Ming Yang, Ying Liu, Yun Zuo, Huairong Tang, Ming Yang, Ying Liu, Yun Zuo, Huairong Tang

Abstract

The European Working Group on Sarcopenia in Older People (EWGSOP) recently published an updated version (EWGSOP2). We aimed to compare the predictive values of EWGSOP-defined and EWGSOP2-defined sarcopenia for the incidence of falls and hospitalization in older adults. We defined sarcopenia according to the EWGSOP and the EWGSOP2. We further modified the cut-off points of the EWGSOP and EWGSOP2 according to the lowest quintile values of the gender-specific distribution of our study population, named "modified EWGSOP" and "modified EWGSOP2", respectively. We included 384 participants. During the follow-up, 98 participants (26.5%) and 51 participants (13.8%) had at least one fall or hospitalization, respectively. EWGSOP2-defined sarcopenia (hazard ratio [HR] 1.86, 95% confidence interval [CI] 1.22-1.84) and modified EWGSOP2-defined sarcopenia (HR 2.09, 95% CI 1.23-3.55) were significantly associated with an increased incidence of falls, respectively. EWGSOP-defined sarcopenia and modified EWGSOP-defined sarcopenia also have a trend to be associated with the incidence of falls, but the results were not statistically significant. Only modified EWGSOP2-defined sarcopenia (HR 2.07, 95% CI 1.01-4.27) was significantly related to an increased incidence of hospitalization. In conclusion, EWGSOP2-defined sarcopenia performed more sensitive than EWGSOP-defined sarcopenia for predicting the incidence of falls or hospitalization, especially when using the modified cutoffs.

Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
The Kaplan–Meier curves of different sarcopenia definitions for predicting the incidence of self-reported falls during the one-year follow-up.
Figure 2
Figure 2
The Kaplan–Meier curves of different sarcopenia definitions for predicting the incidence of hospitalization during the one-year follow-up.

References

    1. Cruz-Jentoft AJ, Landi F, Topinkova E, Michel JP. Understanding sarcopenia as a geriatric syndrome. Curr Opin Clin Nutr Metab Care. 2010;13:1–7. doi: 10.1097/MCO.0b013e328333c1c1.
    1. Morley JE, Bauer J. The future of sarcopenia. Curr Opin Clin Nutr Metab Care. 2019;22:1–3.
    1. Witham MD, Stott DJ. A new dawn for sarcopenia. Age Ageing. 2019;48:2–3. doi: 10.1093/ageing/afy171.
    1. Drew L. Fighting the inevitability of ageing. Nature. 2018;555:S15–S17. doi: 10.1038/d41586-018-02479-z.
    1. Dupuy C, et al. Searching for a relevant definition of sarcopenia: results from the cross-sectional EPIDOS study. J Cachexia Sarcopeni. 2015;6:144–154. doi: 10.1002/jcsm.12021.
    1. Morley JE, Malmstrom TK. Can sarcopenia be diagnosed without measurements? Eur Geriatr Med. 2014;5:291–293. doi: 10.1016/j.eurger.2014.07.014.
    1. Cruz-Jentoft AJ, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39:412–423. doi: 10.1093/ageing/afq034.
    1. Marzetti E, et al. Sarcopenia: an overview. Aging Clin Exp Res. 2017;29:11–17. doi: 10.1007/s40520-016-0704-5.
    1. Landi F, et al. Sarcopenia: An Overview on Current Definitions, Diagnosis and Treatment. Curr Protein Pept Sci. 2018;19:633–638. doi: 10.2174/1389203718666170607113459.
    1. Cruz-Jentoft AJ, et al. Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing. 2019;48:601. doi: 10.1093/ageing/afz046.
    1. Arai H. Sarcopenia diagnostic criteria update by EWGSOP: what has been changed? Eur Geriatr Med. 2018;9:733–734. doi: 10.1007/s41999-018-0117-4.
    1. Yang M, et al. Screening Sarcopenia in Community-Dwelling Older Adults: SARC-F vs SARC-F Combined With Calf Circumference (SARC-CalF) J Am Med Dir Assoc. 2018;19:277.e271–277. doi: 10.1016/j.jamda.2017.08.011.
    1. Delmonico MJ, et al. Alternative definitions of sarcopenia, lower extremity performance, and functional impairment with aging in older men and women. J Am Geriatr Soc. 2007;55:769–774. doi: 10.1111/j.1532-5415.2007.01140.x.
    1. Newman AB, et al. Sarcopenia: alternative definitions and associations with lower extremity function. J Am Geriatr Soc. 2003;51:1602–1609. doi: 10.1046/j.1532-5415.2003.51534.x.
    1. Scott D, et al. Operational definitions of sarcopenia and their associations with 5-year changes in falls risk in community-dwelling middle-aged and older adults. Osteoporosis Int. 2014;25:187–193. doi: 10.1007/s00198-013-2431-5.
    1. Buchner DM, et al. Development of the common data base for the FICSIT trials. J Am Geriatr Soc. 1993;41:297–308. doi: 10.1111/j.1532-5415.1993.tb06708.x.
    1. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: a nonparametric approach. Biometrics. 1988;44:837–845. doi: 10.2307/2531595.
    1. Vieira ER, Palmer RC, Chaves PH. Prevention of falls in older people living in the community. BMJ. 2016;353:i1419. doi: 10.1136/bmj.i1419.
    1. Bischoff-Ferrari HA, et al. Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older. Osteoporos Int. 2015;26:2793–2802. doi: 10.1007/s00198-015-3194-y.
    1. Landi F, et al. Sarcopenia as a risk factor for falls in elderly individuals: Results from the ilSIRENTE study. Clin Nutr. 2012;31:652–658. doi: 10.1016/j.clnu.2012.02.007.
    1. Gadelha AB, et al. Severity of sarcopenia is associated with postural balance and risk of falls in community-dwelling older women. Exp Aging Res. 2018;44:258–269. doi: 10.1080/0361073X.2018.1449591.
    1. Aibar-Almazan A, et al. Sarcopenia and sarcopenic obesity in Spanish community-dwelling middle-aged and older women: Association with balance confidence, fear of falling and fall risk. Maturitas. 2018;107:26–32. doi: 10.1016/j.maturitas.2017.10.001.
    1. Clynes MA, et al. Definitions of Sarcopenia: Associations with Previous Falls and Fracture in a Population Sample. Calcified Tissue Int. 2015;97:445–452. doi: 10.1007/s00223-015-0044-z.
    1. Schaap LA, van Schoor NM, Lips P, Visser M. Associations of Sarcopenia Definitions, and Their Components, With the Incidence of Recurrent Falling and Fractures: The Longitudinal Aging Study Amsterdam. J Gerontol A-Biol. 2018;73:1199–1204. doi: 10.1093/gerona/glx245.
    1. Sim M, et al. Utility of four sarcopenia criteria for the prediction of falls-related hospitalization in older Australian women. Osteoporos Int. 2019;30:167–176. doi: 10.1007/s00198-018-4755-7.
    1. Woo N, Kim SH. Sarcopenia influences fall-related injuries in community-dwelling older adults. Geriatr Nurs. 2014;35:279–282. doi: 10.1016/j.gerinurse.2014.03.001.
    1. Dent E, et al. International Clinical Practice Guidelines for Sarcopenia (ICFSR): Screening, Diagnosis and Management. J Nutr Health Aging. 2018;22:1148–1161. doi: 10.1007/s12603-018-1139-9.
    1. Zhang XM, et al. Sarcopenia as a predictor of hospitalization among older people: a systematic review and meta-analysis. BMC Geriatr. 2018;18:188. doi: 10.1186/s12877-018-0878-0.
    1. Cawthon PM, et al. Clinical Definitions of Sarcopenia and Risk of Hospitalization in Community-Dwelling Older Men: The Osteoporotic Fractures in Men Study. J Gerontol A Biol Sci Med Sci. 2017;72:1383–1389. doi: 10.1093/gerona/glw327.
    1. Bianchi L, et al. The Predictive Value of the EWGSOP Definition of Sarcopenia: Results From the InCHIANTI Study. J Gerontol A-Biol. 2016;71:259–264. doi: 10.1093/gerona/glv129.
    1. Yang N, et al. Relationship between muscle strength and fall episodes among the elderly: the Yilan study, Taiwan. BMC Geriatr. 2018;18:90. doi: 10.1186/s12877-018-0779-2.
    1. Moreland J, et al. Muscle Weakness and Falls in Older Adults: A Systematic Review and Meta‐Analysis. J Am Geriatr Soc. 2004;2:1121–1129. doi: 10.1111/j.1532-5415.2004.52310.x.

Source: PubMed

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