Clinical experience with an in-NICU magnetic resonance imaging system

Kirsten R Thiim, Elizabeth Singh, Srinivasan Mukundan, P Ellen Grant, Edward Yang, Mohamed El-Dib, Terrie E Inder, Kirsten R Thiim, Elizabeth Singh, Srinivasan Mukundan, P Ellen Grant, Edward Yang, Mohamed El-Dib, Terrie E Inder

Abstract

Objective: To evaluate the utility of the 1 Tesla (1 T) Embrace (Aspect Imaging) neonatal magnetic resonance imaging (MRI) scanner in a level III NICU.

Study design: Embrace brain MRI findings for 207 infants were reviewed, including 32 scans directly compared within 5 days with imaging on a 3 T Siemens Trio. Clinical MRI scan abnormalities were also compared to cranial ultrasound findings.

Result: Of the 207 Embrace brain MRIs, 146 (70.5%) were obtained for clinical indications and 61 (29.5%) were research cases. Abnormal findings were found in 80 scans, most commonly hemorrhage and white matter injury. Notable findings included a stroke, medullary brainstem tumor, and polymicrogyria. In the 1 T versus 3 T comparison cohort, results were discordant in only one infant with punctate foci of susceptibility noted only on the 3 T scan.

Conclusion: The Embrace MRI scans detected clinically relevant brain abnormalities and in a subset were clinically comparable to 3 T scans.

Conflict of interest statement

TEI and PEG are members of the Scientific Advisory Board for Aspect Imaging.

© 2022. The Author(s), under exclusive licence to Springer Nature America, Inc.

Figures

Fig. 1. Image comparison of MRI findings…
Fig. 1. Image comparison of MRI findings on the 1 Tesla Embrace (left) and 3 Tesla scanners (right).
a Siemens Trio: sagittal T2 weighted imaging shows perisylvian polymicrogyria (arrows). b Siemens Prisma: axial diffusion weighted imaging shows left occipital PCA infarct (arrow). PCA: posterior cerebral artery. c Siemens Verio: sagittal T2 weighted images show left medullary brainstem tumor (arrow).
Fig. 2. Compassionate care cases.
Fig. 2. Compassionate care cases.
a Very preterm infant. Axial T1 weighted image (left) and T2 weighted image (right) show ventriculomegaly and intraventricular hemorrhage. b Extremely preterm infant with respiratory failure and gram-negative E. Coli sepsis. Axial T2 weighted image left shows intraventricular hemorrhage with regions of medullary vein thromboses (left). Axial DWI (middle) and ADC map (right) show severe diffuse white matter and thalamic decreased diffusion consistent with severe diffuse injury. c Term infant scanned on day 4 of life. Axial T2 weighted image (left), axial Diffusion Weighted Image (middle), and axial ADC map (right) in a neonate with hypoxic ischemic encephalopathy shows severe diffuse injury on DWI.

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