Usefulness of Tokuhashi Score in Survival Prediction of Patients Operated for Vertebral Metastatic Disease

Marcelo Gruenberg, Maximiliano E Mereles, Gastón O Camino Willhuber, Marcelo Valacco, Matias G Petracchi, Carlos A Solá, Marcelo Gruenberg, Maximiliano E Mereles, Gastón O Camino Willhuber, Marcelo Valacco, Matias G Petracchi, Carlos A Solá

Abstract

Study design: Retrospective study.

Objective: Spinal metastasis can produce pain, deformity, neurological compromise and can decrease life expectancy. Surgical management is usually indicated for pain control, neurological decompression, and to avoid deformity progression. Tokuhashi et al created a scoring system to estimate survival and stratify surgical treatment based on established parameters. Our objective was to evaluate the usefulness of Tokuhashi scoring (TS) system by comparing the predicted and real survival times and analyze the survival time according to the type of tumor.

Methods: From 2004 to 2014, 105 patients with vertebral metastasis who underwent surgical treatment were enrolled and retrospectively analyzed. Preoperative TS was performed in all cases. Patients were classified into 3 groups according to TS; group 1 (TS 0-8), group 2 (TS 9-11), and group 3 (TS 12-15). Patients' average age was 61.5 years, main primary tumor site were as follows: kidney (23%), lung (19%), and breast (18%).

Results: The Tokuhashi general concordance was 67.6%. Per group concordance was as follows: group 1 80%, in group 2, only 33% of concordance was observed. In group 3, 100% of concordance was observed. In group 2, the most common primary sites were breast and kidney and the mean survival was 20 and 22.3 months, respectively, both longer than that expected for this group.

Conclusions: Tokuhashi concordance was acceptable in our study, particularly in lower and higher scores. The lesser concordance observed in group 2 (33.3%) was observed in almost all tumors. For our practice, TS constitutes an acceptable tool to define survival, particularly in lower and higher scores.

Keywords: metastatic survival; revised Tokuhashi score; spinal metastases; vertebral metastatic disease.

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Comparison concordance in the different groups. The x-axis shows 2 bars in each group reflecting patients real (black) and expected (gray) survival.
Figure 2.
Figure 2.
The Kaplan-Meier survival figures. Log rank test P < .05.

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