Fat biopsy from a pocket of cardiac implantable electronic device: An alternative diagnostic option for cardiac amyloidosis
Ryo Takano, Nobuhiko Ueda, Atsushi Okada, Manabu Matsumoto, Yoshihiko Ikeda, Kinta Hatakeyama, Chisato Izumi, Kengo Kusano, Ryo Takano, Nobuhiko Ueda, Atsushi Okada, Manabu Matsumoto, Yoshihiko Ikeda, Kinta Hatakeyama, Chisato Izumi, Kengo Kusano
No abstract availableKeywords: Amyloid cardiomyopathy; Atrioventricular block; Biopsy; Cardiac implantable electronic device; Conduction disease; Pacemaker; Subcutaneous fat; Transthyretin.
Figures
A: Electrocardiogram (ECG) showing sinus rhythm, intraventricular conduction delay with indeterminate axis, QS wave in leads V1–V3, and low R-wave amplitude in lead V4. B: Echocardiogram showing left ventricular hypertrophy and apical sparing pattern. C: Telemetry ECG showing an episode of intermittent 2:1 advanced atrioventricular block.
A: Two samples of 4-mm-sized subcutaneous fat from the pacemaker pocket. B: Congo red staining of fat tissue showing the salmon pink color. C: Congo red staining under polarized light showing the apple green birefringence. D: Immunohistochemical staining was positive for transthyretin.
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Source: PubMed