Opt-out universal HCV and HIV screening in a Canadian emergency room: a cross-sectional study

Valerie Martel-Laferriere, Jean-Guy Baril, Isabelle Alarie, Judith Leblanc, José Côté, Emmanuelle Jourdenais, Damy Horth, Gilles Lambert, Cécile Tremblay, Valerie Martel-Laferriere, Jean-Guy Baril, Isabelle Alarie, Judith Leblanc, José Côté, Emmanuelle Jourdenais, Damy Horth, Gilles Lambert, Cécile Tremblay

Abstract

Objectives: To determine the prevalence of undiagnosed hepatitis C virus (HCV) and HIV cases in a population sample tested in the emergency room (ER) and to evaluate linkage-to-care.

Setting: Canadian university hospital.

Participants: Adults born after 1945 who consulted at ER for any condition and on any shift were included. Patients unable to opt-out were excluded.

Interventions: ER nurse confirmed patients' eligibility and provided them with the option to opt-out. A physician met patients with a new diagnosis. Linkage-to-care was assessed 3 months postdiagnosis. Patients newly diagnosed with HCV were considered linked if they had an HCV RNA test, genotype, liver fibrosis evaluation, and if indicated, treatment prescription. Patients newly diagnosed with HIV were considered linked to care if they had an HIV serology confirmation test, viral load, CD4 cell count and started antiretroviral therapy.

Primary and secondary outcome measures: Primary objective: to determine the prevalence (overall and undiagnosed cases) of HIV and HCV among the patients who consult the ER. Secondary objectives: to determine the proportion of patients who opt-out, assess the adherence of emergency staff to the offer of testing, determine the proportion of patients linked to care at 3 months.

Results: Among 6350 eligible patients informed of the screening programme, 62.1% of patients were tested for at least one virus (HIV: 3905; HCV: 3910). 25% patients opted-out, 12% were not tested for organisational reasons, 0.3% (18) patients were HCV-HIV coinfected. Overall prevalence of HCV and HIV cases were 1.9% and 1.2%, respectively. Prevalence of new cases was 0.23% (95% CI 0.12% 0.45%) for HCV and 0.05% (95% CI 0.01% to 0.20%) for HIV. Among the new cases, only two HCV-infected and one HIV-infected patients were linked-to-care 3 months postdiagnosis.

Conclusions: Identification of new cases of HCV and HIV through universal screening at the ER and linkage-to-care were both low.

Trial registration number: NCT03595527; Results.

Keywords: HIV & AIDS; accident & emergency medicine; hepatology.

Conflict of interest statement

Competing interests: VM-L: research grants/consultant: Gilead Sciences, Merck, Abbvie, research material: Cepheids; J-GB: research grants: GlaxoSmithKline, Merck, and Gilead Sciences, consultant: ViiV Healthcare, Merck, and Gilead Sciences; CT: research grants: ViiV, Merck, Gilead Sciences, consultant: Merck, Gilead Sciences, ViiV. IA, JL, JC, EJ, DH and GL have no competing interests to disclose.

© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Figures

Figure 1
Figure 1
Enrolment and outcomes of screening. HCV, hepatitis C virus.
Figure 2
Figure 2
Proportion of people tested for HCV and prevalence of undiagnosed HCV cases by birth cohort. HCV, hepatitis C virus.

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