An update on vaccines against Shigella
Shai Ashkenazi, Dani Cohen, Shai Ashkenazi, Dani Cohen
Abstract
Despite intensive research efforts for more than 60 years, utilizing diverse vaccine strategies, a safe and efficacious vaccine against shigellosis is not available yet. We are currently witnessing innovative approaches based on elucidation of the virulence mechanisms of Shigella, understanding the immune response to the pathogen and progress in molecular technology for developing Shigella vaccines. It is hoped that these will lead to a licensed effective Shigella vaccine to protect humans against the significant worldwide morbidity and mortality caused by this microorganism.
Keywords: Shigellosis; diarrhea; gastroenteritis; prevention; vaccine.
Conflict of interest statement
Conflict of interest statement: The authors declare no conflicts of interest in preparing this article.
Source: PubMed