Autologous Platelet-Rich Plasma Eye Drops for the Treatment of Post-LASIK Chronic Ocular Surface Syndrome
Jorge L Alio, Alejandra E Rodriguez, Ahmed A Abdelghany, Renan F Oliveira, Jorge L Alio, Alejandra E Rodriguez, Ahmed A Abdelghany, Renan F Oliveira
Abstract
Purpose: To evaluate the efficacy of autologous platelet-rich plasma (E-PRP) eye drops for the treatment of chronic ocular surface syndrome (OSS) following laser in situ keratomileusis (LASIK).
Methods: This prospective interventional consecutive clinical study include 156 eyes of 80 patients affected by post-LASIK chronic OSS who were treated with autologous E-PRP 6 times a day as monotherapy for 6 weeks.
Results: Dry eye symptoms improved in 85% of the cases. A decrease in at least one quadrant to total disappearance on CFS was observed in 89.6% of the patients who had positive CFS before treatment. Three eyes presented severe punctate keratitis (1.9%) at baseline, all of which healed completely. Conjunctival hyperemia improved in 93.3% of the patients with previous signs of ocular surface inflammation. There was a significant improvement in logMAR CDVA from 0.14 ± 0.19 to 0.06 ± 0.12 (p = 0.000), and 74 (71.4%) eyes improved at least 1 line in CDVA.
Conclusion: Monotherapy with autologous E-PRP is a well-tolerated, safe, and effective treatment for the management of post-LASIK ocular surface syndrome.
Precis: Monotherapy with autologous platelet-rich plasma eye drops has been shown to be an adequate option for the treatment of post-LASIK chronic ocular surface syndrome. This trial is registered with NCT03322917.
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References
- Solomon K. D., Fernández de Castro L. E., Sandoval H. P., et al. LASIK world literature review: quality of life and patient satisfaction. Ophthalmology. 2009;116(4):691–701. doi: 10.1016/j.ophtha.2008.12.037.
- Nettune G. R., Pflugfelder S. C. Post-LASIK tear dysfunction and dysesthesia. The Ocular Surface. 2010;8(3):135–145. doi: 10.1016/S1542-0124(12)70224-0.
- Alio J. L., Pastor S., Ruiz-Colecha J., Rodriguez A., Artola A. Treatment of ocular surface syndrome after LASIK with autologous platelet-rich plasma. Journal of Refractive Surgery. 2007;23(6):617–619.
- Wilson S. E., Ambrosio R., Jr. Laser in situ keratomileusis-induced neurotrophic epitheliopathy. American Journal of Ophthalmology. 2001;132(3):405–406. doi: 10.1016/S0002-9394(01)00995-3.
- Ambrósio R., Jr., Tervo T., Wilson S. E. LASIK-associated dry eye and neurotrophic epitheliopathy: pathophysiology and strategies for prevention and treatment. Journal of Refractive Surgery. 2008;24(4):396–407.
- Toda I. LASIK and the ocular surface. Cornea. 2008;27(Supplement 1):S70–S76. doi: 10.1097/ICO.0b013e31817f42c0.
- Albietz J. M., Lenton L. M., Franzco, McLennan S. G. Chronic dry eye and regression after laser in situ keratomileusis for myopia. Journal of Cataract & Refractive Surgery. 2004;30(3):675–684. doi: 10.1016/j.jcrs.2003.07.003.
- Bower K. S., Sia R. K., Ryan D. S., Mines M. J., Dartt D. A. Chronic dry eye in photorefractive keratectomy and laser in situ keratomileusis: manifestations, incidence, and predictive factors. Journal of Cataract and Refractive Surgery. 2015;41(12):2624–2634. doi: 10.1016/j.jcrs.2015.06.037.
- Shoja M. R., Besharati M. R. Dry eye after LASIK for myopia: incidence and risk factors. European Journal of Ophthalmology. 2007;17(1):1–6.
- Chao C., Golebiowski B., Stapleton F. The role of corneal innervation in LASIK-induced neuropathic dry eye. The Ocular Surface. 2014;12(1):32–45. doi: 10.1016/j.jtos.2013.09.001.
- Linna T. U., Vesaluoma M. H., Perez-Santonja J. J., Petroll W. M., Alio J. L., Tervo T. M. Effect of myopic LASIK on corneal sensitivity and morphology of subbasal nerves. Investigative Ophthalmology & Visual Science. 2000;41(2):393–397.
- Yu E. Y. W., Leung A., Rao S., Lam D. S. C. Effect of laser in situ keratomileusis on tear stability. Ophthalmology. 2000;107(12):2131–2135. doi: 10.1016/s0161-6420(00)00388-2.
- Rodriguez-Prats J. L., Hamdi I. M., Rodriguez A. E., Galal A., Alio J. L. Effect of suction ring application during LASIK on goblet cell density. Journal of Refractive Surgery. 2007;23(6):559–562.
- Yazawa M., Ogata H., Nakajima T., Mori T., Watanabe N., Handa M. Basic studies on the clinical applications of platelet-rich plasma. Cell Transplantation. 2003;12(5):509–518. doi: 10.3727/000000003108747073.
- Tsubota K., Goto E., Fujita H., et al. Treatment of dry eye by autologous serum application in Sjögren’s syndrome. British Journal of Ophthalmology. 1999;83(4):390–395. doi: 10.1136/bjo.83.4.390.
- Noda-Tsuruya T., Asano-Kato N., Toda I., Tsubota K. Autologous serum eye drops for dry eye after LASIK. Journal of Refractive Surgery. 2006;22(1):61–66.
- Alio J. L., Rodriguez A. E., WróbelDudzińska D. Eye platelet-rich plasma in the treatment of ocular surface disorders. Current Opinion in Ophthalmology. 2015;26(4):325–332. doi: 10.1097/ICU.0000000000000169.
- Alio J. L., Arnalich-Montiel F., Rodriguez A. E. The role of “eye platelet rich plasma” (E-PRP) for wound healing in ophthalmology. Current Pharmaceutical Biotechnology. 2012;13(7):1257–1265. doi: 10.2174/138920112800624355.
- Alio J. L., Abad M., Artola A., Rodriguez-Prats J. L., Pastor S., Ruiz-Colecha J. Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology. 2007;114(7):1286–1293.e1. doi: 10.1016/j.ophtha.2006.10.044.
- Alio J. L., Colecha J. R., Pastor S., Rodriguez A., Artola A. Symptomatic dry eye treatment with autologous platelet-rich plasma. Ophthalmic Research. 2007;39(3):124–129. doi: 10.1159/000100933.
- Javaloy J., Alió J. L., Rodriguez A. E., Vega A., Muñoz G. Effect of platelet-rich plasma in nerve regeneration after LASIK. Journal of Refractive Surgery. 2013;29(3):213–219. doi: 10.3928/1081597X-20130129-04.
- Ortuno-Prados V. J., Alio J. L. Treatment of a neurotrophic corneal ulcer with solid platelet-rich plasma and Tutopatch®. Archivos de la Sociedad Española de Oftalmología. 2011;86(4):121–123. doi: 10.1016/S2173-5794(11)70023-8.
- The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007) The Ocular Surface. 2007;5(2):75–92. doi: 10.1016/s1542-0124(12)70081-2.
- Lemp M. A., Baudouin C., Amrane M., Ismail D., Garrigue J. S., Buggage R. R. Poor correlation between dry eye disease (DED) signs and symptoms in a phase III randomized clinical trial. Investigative Ophthalmology & Visual Science. 2011;52:p. 3821.
- Baudouin C., Aragona P., Van Setten G., et al. Diagnosing the severity of dry eye: a clear and practical algorithm. British Journal of Ophthalmology. 2014;98(9):1168–1176. doi: 10.1136/bjophthalmol-2013-304619.
- Belmonte C., Carmen Acosta M., Gallar J. Neural basis of sensation in intact and injured corneas. Experimental Eye Research. 2004;78(3):513–525. doi: 10.1016/j.exer.2003.09.023.
- The epidemiology of dry eye disease: report of the Epidemiology Subcommittee of the International Dry Eye WorkShop (2007) The Ocular Surface. 2007;5(2):93–107. doi: 10.1016/S1542-0124(12)70082-4.
- Chao C., Golebiowski B., Zhao X., Chen S., Zhou S., Stapleton F. Long-term effects of LASIK on corneal innervation and tear neuropeptides and the associations with dry eye. Journal of Refractive Surgery. 2016;32(8):518–524. doi: 10.3928/1081597X-20160603-01.
- Battat L., Macri A., Dursun D., Pflugfelder S. C. Effects of laser in situ keratomileusis on tear production, clearance, and the ocular surface. Ophthalmology. 2001;108(7):1230–1235. doi: 10.1016/S0161-6420(01)00623-6.
- De Paiva C. S., Chen Z., Koch D. D. The incidence and risk factors for developing dry eye after myopic LASIK. American Journal of Ophthalmology. 2006;141(3):438–445. doi: 10.1016/j.ajo.2005.10.006.
- Donnenfeld E. D., Solomon K., Perry H. D., et al. The effect of hinge position on corneal sensation and dry eye after LASIK. Ophthalmology. 2003;110(5):1023–1029. doi: 10.1016/S0161-6420(03)00100-3.
- Toda I., Asano-Kato N., Komai-Hori Y., Tsubota K. Dry eye after laser in situ keratomileusis. American Journal of Ophthalmology. 2001;132(1):1–7. doi: 10.1016/S0002-9394(01)00959-X.
Source: PubMed