Comparison of the Relative Renal Function Calculated with 99mTc-Diethylenetriaminepentaacetic Acid and 99mTc-Dimercaptosuccinic Acid in Children

Tanju Çelik, Hülya Yalçin, Emel Ceylan Günay, Aynur Özen, Cahit Özer, Tanju Çelik, Hülya Yalçin, Emel Ceylan Günay, Aynur Özen, Cahit Özer

Abstract

The aim was to compare the relative renal functions measured with technetium-99m dimercaptosuccinic acid (99mTc-DMSA) and technetium-99m diethylenetriaminepentaacetic acid (99mTc-DTPA) in children with renal diseases. Relative renal function of 128 children who applied to three hospitals from 2009 to 2011 were analyzed retrospectively. The mean value measured with 99mTc-DTPA and 99mTc-DMSA were 51.58 ± 14.95 and 51.96 ± 14.99 for the right kidney, 47.87 ± 15.27 and 47.94 ± 15.17 for the left kidney, respectively. A significant positive correlation was found between the relative renal functions (r = 0.963, P < 0.001). In Bland-Altman plots, the mean difference between two methods was 0.7 and the correlation limits were between 10.1 and-10.8. As a result, although 99mTc-DMSA is accepted as the most reliable method for the determination of relative renal function, 99mTc-DTPA can be another choice for the calculation of relative renal function without a complementary DMSA scan particularly in pediatric patients who require renogram curve and GFR calculations.

Keywords: Child; relative renal function; technetium-99m diethylenetriaminepentaacetic acid; technetium-99m dimercaptosuccinic acid.

Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Bland-Altman plot of dimercaptosuccinic acid and diethylenetriaminepentaacetic acid for right kidney
Figure 2
Figure 2
Bland-Altman plot of dimercaptosuccinic acid and diethylenetriaminepentaacetic acid for left kidney

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