Clinical outcomes of silk patch in acute tympanic membrane perforation

Jun Ho Lee, Joong Seob Lee, Dong-Kyu Kim, Chan Hum Park, Hae Ran Lee, Jun Ho Lee, Joong Seob Lee, Dong-Kyu Kim, Chan Hum Park, Hae Ran Lee

Abstract

Objectives: The silk patch is a thin transparent patch that is produced from silk fibroin. In this study, we investigated the treatment effects of the silk patch in patients with traumatic tympanic membrane perforation (TTMP).

Methods: The closure rate, otorrhea rate, and closure time in all patients and the closure time in successful patients were compared between the paper patch and silk patch groups.

Results: Demographic data (gender, site, age, traumatic duration, preoperative air-bone gap, and perforation size and location) were not significantly different between the two groups. The closure rate and otorrhea rate were not significantly different between the two groups. However, the closure time was different between the two groups (closure time of all patients, P=0.031; closure time of successful patients, P=0.037).

Conclusion: The silk patch which has transparent, elastic, adhesive, and hyper-keratinizing properties results in a more efficient closure time than the paper patch in the treatment of TTMP patients. We therefore believe that the silk patch should be recommended for the treatment of acute tympanic membrane perforation.

Keywords: Ear, Middle; Fibroins; Silk; Tympanic Membrane Perforation.

Conflict of interest statement

CONFLICT OF INTEREST: No potential conflict of interest relevant to this article was reported.

Figures

Fig. 1. (A) Scanning electron microscope image…
Fig. 1. (A) Scanning electron microscope image with nonporous structure. (B) Thin transparent silk patch.
Fig. 2. Silk patch (black arrow) applied…
Fig. 2. Silk patch (black arrow) applied the group of small sized tympanic membrane (TM) perforation. (A) The pack of silk patch was opened and silk patch was immersed in normal saline for about 3 to 4 minutes to get the flexibility. (B) Right TM findings of silk patch applied 48 years old patient. He had the silk patch apply at 7 days after trauma. The complete perforation healing status of TM shows at postoperation 2 weeks. (C) Pure tone audiometry shows nonvisible air-bone gap at postoperation 2 weeks. Pre-Op, preoperation; Post-Op, postoperation.
Fig. 3. Silk patch (black arrow) applied…
Fig. 3. Silk patch (black arrow) applied the group of medium sized tympanic membrane (TM) perforation. (A) Left TM findings of silk patch applied 62 years old patient. He had the silk patch apply at 2 weeks after trauma. TM findings show the complete perforation healing status of TM at postoperation 2 weeks. (B) Pure tone audiometry shows the improved air-bone gap at postoperation 1 month. Pre-Op, preoperation; Post-Op, postoperation.

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