Efficacy of different methods used for dry socket prevention and risk factor analysis: A systematic review

M Taberner-Vallverdú, M-Á Sánchez-Garcés, C Gay-Escoda, M Taberner-Vallverdú, M-Á Sánchez-Garcés, C Gay-Escoda

Abstract

Background: Dry socket is one of the most common complications that develops after the extraction of a permanent tooth, and its prevention is more effective than its treatment.

Objectives: Analyze the efficacy of different methods used in preventing dry socket in order to decrease its incidence after tooth extraction.

Material and methods: A Cochrane and PubMed-MEDLINE database search was conducted with the search terms "dry socket", "prevention", "risk factors", "alveolar osteitis" and "fibrynolitic alveolitis", both individually and using the Boolean operator "AND". The inclusion criteria were: clinical studies including at least 30 patients, articles published from 2005 to 2015 and written in English. The exclusion criteria were case reports and nonhuman studies.

Results: 30 publications were selected from a total of 250. Six of the 30 were excluded after reading the full text. The final review included 24 articles: 9 prospective studies, 2 retrospective studies and 13 clinical trials. They were stratified according to their level of scientific evidence using SIGN criteria (Scottish Intercollegiate Guidelines Network).

Conclusions: All treatments included in the review were aimed at decreasing the incidence of dry socket. Locally administering chlorhexidine or applying platelet-rich plasma reduces the likelihood of developing this complication. Antibiotic prescription does not avoid postoperative complications after lower third molar surgery. With regard to risk factors, all of the articles selected suggest that patient age, history of previous infection and the difficulty of the extraction are the most common predisposing factors for developing dry socket. There is no consensus that smoking, gender or menstrual cycles are risk factors. Taking the scientific quality of the articles evaluated into account, a level B recommendation has been given for the proposed-procedures in the prevention of dry socket.

Conflict of interest statement

Conflict of interest statement:The authors of this paper have no conflict of interest in reporting this publication.

Figures

Figure 1
Figure 1
Flow of articles through the systematic review.

References

    1. Burgoyne CC, Giglio JA, Reese SE, Sima AP, Laskin DM. The efficacy of a topical anesthetic gel in the relief of pain associated with localized alveolar osteitis. J Oral Maxillofac Surg. 2010;68:144–8.
    1. Cardoso CL, Rodrigues MTV, Ferreira Júnior O, Garlet GP, de Carvalho PSP. Clinical concepts of dry socket. J Oral Maxillofac Surg. 2010;68:1922–32.
    1. Torres-Lagares D, Serrera-Figallo MA, Romero-Ruíz MM, Infante-Cossío P, García-Calderón M, Gutiérrez-Pérez JL. Update on dry socket: A review of the literature. Med Oral Patol Oral Cir Bucal. 2005;10:77–85.
    1. Blum IR. Contemporary views on dry socket (alveolar osteitis): A clinical appraisal of standardization, aetiopathogenesis and management: A critical review. Int J Oral Maxillofac Surg. 2002;31:309–17.
    1. Bowe DC, Rogers S, Stassen LFA. The management of dry socket/alveolar osteitis. J Ir Dent Assoc. 2011;57:305–10.
    1. Nusair YM, Goussous ZM. Quantifying the healing of dry socket using a clinical volumetric method. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006;101:e89–95.
    1. Noroozi AR, Philbert RF. Modern concepts in understanding and management of the "dry socket" syndrome: Comprehensive review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:30–5.
    1. Kolokythas A, Olech E, Miloro M. Alveolar osteitis: A comprehensive review of concepts and controversies. Int J Dent. 2010;2010:249073.
    1. Cardoso CL, Ferreir Júnior O, Carvalho PS, Dionísio TJ, Cestari TM, Garlet GP. Experimental dry socket. Acta Cir Bras. 2011;26:365–72.
    1. de Carvalho PS, Mariano RC, Okamoto T. Treatment of fibrinolytic alveolitis. Braz Dent J. 1997;8:3–8.
    1. Taberner-Vallverdú M, Nazir M, Sánchez-Garcés MA, Gay-Escoda C. Efficacy of different methods used for dry socket management: A systematic review. Med Oral Patol Oral Cir Bucal. 2015;20:633–9.
    1. Daly B, Sharif MO, Newton T, Jones K, Worthington H V. Local interventions for the management of alveolar osteitis (dry socket) Cochrane database Syst Rev. 2012;12:CD006968.
    1. SIGN 50: A guideline developer's handbook . Edinburgh : SIGN ; 2001.
    1. Hita-Iglesias P, Torres-Lagares D, Flores-Ruiz R, Magallanes-Abad N, Basallote-Gonzalez M, Gutierrez-Perez JL. Effectiveness of clorhexidine gel versus clorhexidine rinse in reducing alveolar osteitis in mandibular third molar surgery. JOralMaxillofacSurg. 2008;66:441–5.
    1. Rodríguez-Pérez M, Bravo-Pérez M, Sánchez-López JD, Muñoz-Soto E, Romero-Olid MN, Baca-García P. Effectiveness of 1% versus 0.2% clorhexidine gels in reducing alveolar osteitis from mandibular third molar surgery: A randomized, double-blind clinical trial. Med Oral Patol Oral Cir Bucal. 2013;18:693–700.
    1. Freudenthal N, Sternudd M, Jansson L, Wannfors K. A double-blind randomized study evaluating the effect of intra-alveolar clorhexidine gel on alveolar osteitis after removal of mandibular third molars. J Oral Maxillofac Surg. 2015;73:600–5.
    1. Rubio-Palau J, Garcia-Linares J, Hueto-Madrid JA, González-Lagunas J, Raspall-Martin G, Mareque-Bueno J. Effect of intra-alveolar placement of 0.2% clorhexidine bioadhesive gel on the incidence of alveolar osteitis following the extraction of mandibular third molars. A double-blind randomized clinical trial. Med Oral Patol Oral Cir Bucal. 2015;20:117–22.
    1. Torres-Lagares D, Infante-Cossio P, Gutierrez-Perez JL, Romero-Ruiz MM, Garcia-Calderon M, Serrera-Figallo MA. Intra-alveolar clorhexidine gel for the prevention of dry socket in mandibular third molar surgery. A pilot study. Med Oral Patol Oral Cir Bucal. 2006;11:e179–84.
    1. Torres-Lagares D, Gutierrez-Perez JL, Hita-Iglesias P, Magallanes-Abad N, Flores-Ruiz R, Basallote-Garcia M. Randomized, double-blind study of effectiveness of intra-alveolar application of clorhexidine gel in reducing incidence of alveolar osteitis and bleeding complications in mandibular third molar surgery in patients with bleeding disorders. J Oral Maxillofac Surg. 2010;68:1322–6.
    1. Torres-Lagares D, Gutierrez-Perez JL, Infante-Cossio P, García-Calderón M, Romero-Ruiz MM, Serrera-Figallo MA. Randomized, double-blind study on effectiveness of intra-alveolar clorhexidine gel in reducing the incidence of alveolar osteitis in mandibular third molar surgery. Int J Oral Maxillofac Surg. 2006;35:348–51.
    1. Haraji A, Rakhshan V. Clorhexidine gel and less difficult surgeries might reduce post-operative pain, controlling for dry socket infection and analgesic consumption: A split-mouth controlled randomised clinical trial. J Oral Rehabil. 2015;42:209–19.
    1. Sridhar V, Wali GG, Shyla HN. Evaluation of the perioperative use of 0.2% clorhexidine gluconate for the prevention of alveolar osteítis after the extraction of impacted mandibular third molars: A clinical study. J Maxillofac Oral Surg. 2011;10:101–11.
    1. Jesudasan JS, Wahab PU, Sekhar MR. Effectiveness of 0.2% clorhexidine gel and an eugenol-based paste on postoperative alveolar osteítis in patients having third molars extracted: A randomised controlled clinical trial. Br J Oral Maxillofac Surg. 2015;53:826–30.
    1. Bortoluzzi MC, Capella DL, Barbieri T, Pagliarini M, Cavalieri T, Manfro R. A single dose of amoxicillin and dexamethasone for prevention of postoperative complications in third molar surgery: A randomized, double-blind, placebo controlled clinical trial. J Clin Med Res. 2013;5:26–33.
    1. Lee JY, Do HS, Lim JH, Jang HS, Rim JS, Kwon JJ. Correlation of antibiotic prophylaxis and difficulty of extraction with postoperative inflammatory complications in the lower third molar surgery. Br J Oral Maxillofac Surg. 2014;52:54–7.
    1. Xue P, Wang J, Wu B, Ma Y, Wu F, Hou R. Efficacy of antibiotic prophylaxis on postoperative inflammatory complications in Chinese patients having impacted mandibular third molars removed: A split-mouth, double-blind, self-controlled, clinical trial. Br J Oral Maxillofac Surg. 2015;53:416–20.
    1. Bezerra TP, Studart-Soares EC, Scaparo HC, Pita-Neto IC, Batista SH, Fonteles CS. Prohylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: A split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg) J Oral Maxillofac Surg. 2011;69:333–9.
    1. Kaczmaryk T, Wichlinski J, Stypulkowska J, Zaleska M, Panas M, Woron J. Single-dose and multi-dose clindamycin therapy fails to demonstrate efficacy in preventing infectious and inflammatory complications in third molar surgery. Int J Oral Maxillofac Surg. 2007;36:417–22.
    1. Sanchis JM, Sáez U, Peñarrocha M, Gay-Escoda C. Tetracycline compound placement to prevent dry socket: A postoperative study of 200 impacted mandibular third molars. J Oral Maxillofac Surg. 2004;62:587–91.
    1. Reekie D, Downes P, Devlin CV, Nixon GM, Devlin H. The prevention of "dry socket" with topical metronidazole in general dental practice. Br Dent J. 2006;200:210–3.
    1. Halpern LR, Dodson TB. Does prophylactic administration of systemic antibiotics prevent postoperative inflammatory complications after third molar surgery? J Oral Maxillofac Surg. 2007;65:177–85.
    1. Eshghpour M, Dastmalchi P, Nekooei AH, Nejat A. Effect of platelet-rich fibrin on frequency of alveolar osteitis following mandibular third molar surgery: A double-blinded randomized clinical trial. J Oral Maxillofac Surg. 2014;72:1463–7.
    1. Rutkowski JL, Fennell JW, Kern JC, Madison DE, Johnson DA. Inhibition of alveolar osteitis in mandibular tooth extraction sites using platelet-rich plasma. J Oral Implantol. 2007;33:116–21.
    1. Osunde OD, Adebola RA, Adeoye JB, Bassey GO. Comparative study of the effect of warm saline mouth rinse on complications after dental extractions. Int J Oral Maxillofac Surg. 2014;43:649–53.
    1. Cho H, Jung HD, Kim BJ, Kim CH, Jung YS. Complication rates in patients using absorbable collagen sponges in third molar extraction sockets: A retrospective study. J Korean Assoc Oral Maxillofac Surg. 2015;41:26–9.
    1. Tek M, Akkas I, Toptas O, Ozan F, Sener I, Bereket C. Effects of the topical hemostatic agent Ankaferd Blood Stopper on the incidence of alveolar osteitis after surgical removal of an impacted mandibular third molar. Niger J Clin Pract. 2014;17:75–80.
    1. Tolstunov L. Influence of inmediate post-extraction socket irrigation on development of alveolar osteitis after mandibular third molar removal: A prospective split-mouth study, preliminary report. Br Dent J. 2012;213:597–601.
    1. Eshghpour M, Nejat AH. Dry socket following surgical removal of impacted third molars in an Iranian population: Incidence and risk factors. Niger J Clin Pract. 2013;16:496–500.
    1. Eshghpour M, Rezaei NM, Nejat A. Effect of menstrual cycle on frequency of alveolar osteitis in women undergoing surgical removal of mandibular third molar: A single-blind randomized clinical trial. J Oral Maxillofac Surg. 2013;71:1484–9.
    1. Chuang SK, Perrott DH, Susarla SM, Dodson TB. Risk factors for inflammatory complications following third molar surgery in adults. J Oral Maxillofac Surg. 2008;66:2213–8.
    1. Malkawi Z, Al-Omiri MK, Khraisat A. Risk indicators of postoperative complications following surgical extraction of lower third molars. Med Princ Pract. 2011;20:321–5.
    1. Haraji A, Rakhshan V. Single-dose intra-alveolar clorhexidine gel application, easier surgeries, and younger ages are associated with reduced dry socket risk. J Oral Maxillofac Surg. 2014;72:259–65.
    1. Halabí D, Escobar J, Muñoz C, Uribe S. Logistic regression analysis of risk factors for the development of alveolar osteítis. J Oral Maxillofac Surg. 2012;70:1040–4.
    1. Oginni FO. Dry socket: A prospective study of prevalent risk factors in a Nigerian population. J Oral Maxillofac Surg. 2008;66:2290–5.
    1. Abu Younis MH, Abu Hantash RO. Dry socket: Frequency, clinical picture, and risk factors in a palestinian dental teaching center. Open Dent J. 2011;5:7–12.
    1. Parthasarathi K, Smith A, Chandu A. Factors affecting incidence of dry socket: A prospective community-based study. J Oral Maxillofac Surg. 2011;69:1880–4.
    1. Minguez-Serra MP, Salort-Llorca C, Silvestre-Donat FJ. Clorhexidine in the prevention of dry socket: Effectiveness of different dosage forms and regimens. Med Oral Patol Oral Cir Bucal. 2009;14:e445–9.
    1. Ren YF, Malmstrom HS. Effectiveness of antibiotic prophylaxis in third molar surgery: A meta-analysis of randomized controlled clinical trials. J Oral Maxillofac Surg. 2007;65:1909–21.
    1. Barona-Dorado C, González-Regueiro I, Martín-Ares M, Arias-Irimia O, Martínez-González JM. Efficacy of platelet-rich plasma applied to post-extraction retained lower third molar alveoli. A systematic review. Med Oral Patol Oral Cir Bucal. 2014;19:142–8.
    1. Rakhshan V. Common risk factors for postoperative pain following the extraction of wisdom teeth. J Korean Assoc Oral Maxillofac Surg. 2015;41:59–65.

Source: PubMed

3
Předplatit